Distinct requirements for activation of NKT and NK cells during viral infection

NK cells are key regulators of innate defense against mouse CMV (MCMV). Like NK cells, NKT cells also produce high levels of IFN-γ rapidly after MCMV infection. However, whether similar mechanisms govern activation of these two cell types, as well as the significance of NKT cells for host resistance...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 192; no. 8; pp. 3676 - 3685
Main Authors:	Tyznik, Aaron J, Verma, Shilpi, Wang, Qiao, Kronenberg, Mitchell, Benedict, Chris A
Format:	Journal Article
Language:	English
Published:	United States 15-04-2014
Subjects:	Animals Cell Communication - immunology Cytokines - biosynthesis Cytokines - pharmacology Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - virology Gene Expression Immunity, Innate Interferon-gamma - biosynthesis Interleukin-12 - biosynthesis Interleukin-12 - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - immunology Mice Mice, Knockout Muromegalovirus - immunology Natural Killer T-Cells - drug effects Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - metabolism
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