Role of T cell death in maintaining immune tolerance during persistent viral hepatitis

Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tole...

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Bibliographic Details
Published in:	World journal of gastroenterology : WJG Vol. 19; no. 12; pp. 1877 - 1889
Main Authors:	Larrubia, Juan Ramón, Lokhande, Megha Uttam, García-Garzón, Silvia, Miquel, Joaquín, Subirá, Dolores, Sanz-de-Villalobos, Eduardo
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Co., Limited 28-03-2013
Subjects:	Apoptosis - physiology Apoptosis Regulatory Proteins - physiology Bcl-2-Like Protein 11 Cell Death - immunology Hepatitis, Viral, Human - immunology Hepatitis, Viral, Human - metabolism Humans Immune Tolerance Liver - immunology Liver - pathology Membrane Proteins - physiology Proto-Oncogene Proteins - physiology Review T-Lymphocytes - pathology Specific cytotoxic T lymphocytes T cell death Viral hepatitis Bcl-2 interacting mediator Hepatitis C virus immune tolerance Apoptotic pathways Liver tolerance Apoptosis
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