Cefiderocol, a new antibiotic against multidrug-resistant Gram-negative bacteria

• Published in: Revista española de quimioterapia Vol. 34 Suppl 1; no. Suppl 1; pp. 41 - 43
• Main Authors: Silva, J T, López-Medrano, F
• Format: Journal Article
• Language: English
• Published: Spain Sociedad Española de Quimioterapia 01-09-2021
• Subjects: Adult; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Cefiderocol; Cephalosporins - pharmacology; Cephalosporins - therapeutic use; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections - drug therapy; Humans; Update on Antimicrobial Pharmacotherapy
• ISSN: 0214-3429; 1988-9518
• DOI: 10.37201/req/s01.12.2021

Cefiderocol is a novel catechol-substituted siderophore cephalosporin that binds to the extracellular free iron, and uses the bacterial active iron transport channels to penetrate in the periplasmic space of Gram-negative bacteria (GNB). Cefiderocol overcomes many resistance mechanisms of these bacteria. Cefiderocol is approved for the treatment of complicated urinary tract infections, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in the case of adults with limited treatment options, based on the clinical data from the APEKS-cUTI, APEKS-NP and CREDIBLE-CR trials. In the CREDIBLE-CR trial, a higher all-cause mortality was observed in the group of patients who received cefiderocol, especially those with severe infections due to Acinetobacter spp. Further phase III clinical studies are necessary in order to evaluate cefiderocol´s efficacy in the treatment of serious infections.