Clinical characteristics and outcomes of diffuse large B-cell lymphoma in adolescents and young adults

• Published in: International journal of hematology Vol. 108; no. 2; pp. 161 - 166
• Main Authors: Suzuki, Yasuhiro, Yano, Takahiro, Suehiro, Youko, Iwasaki, Hiromi, Hidaka, Michihiro, Otsuka, Maki, Sunami, Kazutaka, Inoue, Nobumasa, Sawamura, Morio, Ito, Takuo, Iida, Hiroatsu, Nagai, Hirokazu
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-08-2018; Springer Nature B.V
• Subjects: Adolescents; Adults; Age; B-cell lymphoma; Hematology; Lymphocytes B; Lymphoma; Medicine; Medicine & Public Health; Multivariate analysis; Older people; Oncology; Original Article; Patients; Survival; Teenagers; Young adults; Non-Hodgkin lymphoma; Young adults; Adolescents; Clinical practice; Diffuse large B-cell lymphoma
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-018-2449-8

Clinical information regarding non-Hodgkin lymphoma (NHL) in adolescents and young adults (AYA) is lacking. We retrospectively analyzed 1426 consecutively registered patients with newly diagnosed NHL. Of 798 DLBCL patients, 42 (5.3%) were identified as AYA (16–39 years). The characteristics of AYA DLBCL patients showed no significant differences compared to older adult DLBCL patients (age ≥ 40 years). Progression-free survival (PFS) and overall survival (OS) in AYA were similar to those in patients aged 40–60 years. However, in older adult groups, PFS and OS were significantly different according to the age group (40–60, 61–79, and ≥ 80 years). In univariate analysis in AYA, performance status, clinical stage, International Prognostic Index (IPI), and age-adjusted IPI significantly affected both PFS and OS. In multivariate analysis, only clinical stage was identified as an independent predictor among AYA. In conclusion, disease characteristics and outcomes of DLBCL in AYA were nearly the same as those in older adults.