Synthesis of chalcone derivatives on steroidal framework and their anticancer activities

Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to...

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Bibliographic Details
Published in:	Steroids Vol. 72; no. 13; pp. 892 - 900
Main Authors:	Saxena, Hari Om, Faridi, Uzma, Kumar, J.K., Luqman, Suaib, Darokar, M.P., Shanker, Karuna, Chanotiya, Chandan S., Gupta, M.M., Negi, Arvind S.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-11-2007 Elsevier Science
Subjects:	Anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Chalcone Chalcone - analogs & derivatives Erythrocyte Estradiol Estradiol - chemistry Fundamental and applied biological sciences. Psychology Humans Osmotic fragility Vertebrates: endocrinology Erythrocyte Osmotic fragility Anticancer Estradiol Chalcone Antineoplastic agent Estrogen 17β-Estradiol Red blood cell Biosynthesis Ovarian hormone Blood cell Sex steroid hormone
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