Adherence to infliximab treatment in patients with immune-mediated inflammatory diseases from a referral center in Brazil: a cohort study

• Published in: BMC gastroenterology Vol. 24; no. 1; pp. 384 - 13
• Main Authors: Lauton, Priscila Moreira, Pereira, Fernanda Silva, Oliveira, Livia Brito, Brauer, Alline Mikaelle Nunes Wildemberg, de Araújo Costa Beisl Noblat, Lucia, Santana, Genoile Oliveira, Santos, Pablo Moura
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29-10-2024; BioMed Central; BMC
• Subjects: Adherence; Adult; Aged; Analysis; Brazil; Care and treatment; Chronic illnesses; Cohort analysis; Cohort Studies; Crohns disease; Diseases; Dosage and administration; Drug administration; Drug dosages; Drug therapy; Female; Gastrointestinal Agents - therapeutic use; Health aspects; Hospitals; Humans; Immune-mediated inflammatory diseases; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - drug therapy; Inflammatory diseases; Infliximab; Infliximab - therapeutic use; Male; Medical records; Medical research; Medical treatment; Medication Adherence - statistics & numerical data; Medicine, Experimental; Middle Aged; Monoclonal antibodies; Normal distribution; Patient compliance; Patients; Psoriasis; Psoriatic arthritis; Questionnaires; Referral and Consultation - statistics & numerical data; Remission; Remission Induction; Rheumatoid arthritis; Schedules; Sociodemographics; Tumor necrosis factor-α; Brazil; Adherence; Infliximab; Immune-mediated inflammatory diseases
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-024-03455-w

Infliximab therapy is effective in controlling symptoms and attaining clinical remission of immune-mediated inflammatory diseases. However, treatment adherence is essential to achieve the therapeutic objective. This study aimed to determine the rate of adherence to infliximab treatment in patients treated at a referral center at a university hospital.
This ambispective cohort study included patients treated at the Professor Edgard Santos University Hospital (HUPES) referral center of our university hospital between March 2022 and February 2023. Sociodemographic, clinical, and pharmacotherapeutic data were collected from 101 patients through interviews and medical record reviews using a structured form. The adherence rate was defined as the proportion of days covered in a year. Patients who achieved an adherence rate > 80% were considered adherent.
The treatment adherence rate was 91.04%. Individuals with inflammatory bowel diseases had a 39.1% higher risk of non-adherence to treatment compared with other patients in our sample (p < 0,05). Most patients achieved remission or control of the underlying disease activity and had good functional capacities. The main reason for absence on the scheduled date was difficulty traveling to the referral center.
Despite the reported difficulties, treatment adherence was observed to be high. As the study was conducted in a reference unit with multidisciplinary care and continuous monitoring for treatment effectiveness, safety, and adherence, welcoming and good communication between professionals and patients may have contributed to the high adherence rate.