Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential
•Genotoxicity of ZnO NPs has been shown in mammalian cells.•ZnO NPs has been able to induce cell transformation.•An antagonist interaction between ZnO NPs and UVB-light has been demonstrated.•Genotoxic/carcinogenic effects differ between ZnO NPs and the ionic forms. The in vitro genotoxic and the so...
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| Published in: | Journal of hazardous materials Vol. 264; pp. 420 - 429 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
15-01-2014
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| Abstract | •Genotoxicity of ZnO NPs has been shown in mammalian cells.•ZnO NPs has been able to induce cell transformation.•An antagonist interaction between ZnO NPs and UVB-light has been demonstrated.•Genotoxic/carcinogenic effects differ between ZnO NPs and the ionic forms.
The in vitro genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells, either alone or in combination with UVB-light. The comet assay, with and without the use of FPG and Endo III enzymes, the micronucleus assay and the soft-agar colony assay were used. For the comet assay a statistically significant induction of DNA damage, with and without the enzymes, were observed up of 100μg/mL. ZnO NPs were able to increase significantly the frequency of micronuclei, and similar results were observed in the cell transformation assay where such NPs were able to induce cell-anchorage independent growth. These effects were observed at doses up 100μg/mL. Although UVB-light was able to induce genotoxic damage and cell-anchorage growth, a significant antagonist interaction effect was observed in combination with ZnO NPs. These in vitro results, obtained with the selected cell lines, contribute to increase our genotoxicity database on the ZnO NPs effects as well as to open the discussion about their risk in photo-protection sun screens. |
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| AbstractList | The in vitro genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells, either alone or in combination with UVB-light. The comet assay, with and without the use of FPG and Endo III enzymes, the micronucleus assay and the soft-agar colony assay were used. For the comet assay a statistically significant induction of DNA damage, with and without the enzymes, were observed up of 100μg/mL. ZnO NPs were able to increase significantly the frequency of micronuclei, and similar results were observed in the cell transformation assay where such NPs were able to induce cell-anchorage independent growth. These effects were observed at doses up 100μg/mL. Although UVB-light was able to induce genotoxic damage and cell-anchorage growth, a significant antagonist interaction effect was observed in combination with ZnO NPs. These in vitro results, obtained with the selected cell lines, contribute to increase our genotoxicity database on the ZnO NPs effects as well as to open the discussion about their risk in photo-protection sun screens. •Genotoxicity of ZnO NPs has been shown in mammalian cells.•ZnO NPs has been able to induce cell transformation.•An antagonist interaction between ZnO NPs and UVB-light has been demonstrated.•Genotoxic/carcinogenic effects differ between ZnO NPs and the ionic forms. The in vitro genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells, either alone or in combination with UVB-light. The comet assay, with and without the use of FPG and Endo III enzymes, the micronucleus assay and the soft-agar colony assay were used. For the comet assay a statistically significant induction of DNA damage, with and without the enzymes, were observed up of 100μg/mL. ZnO NPs were able to increase significantly the frequency of micronuclei, and similar results were observed in the cell transformation assay where such NPs were able to induce cell-anchorage independent growth. These effects were observed at doses up 100μg/mL. Although UVB-light was able to induce genotoxic damage and cell-anchorage growth, a significant antagonist interaction effect was observed in combination with ZnO NPs. These in vitro results, obtained with the selected cell lines, contribute to increase our genotoxicity database on the ZnO NPs effects as well as to open the discussion about their risk in photo-protection sun screens. |
| Author | Akça, Hakan Demir, Eşref Creus, Amadeu Aksakal, Sezgin Burgucu, Durmuş Turna, Fatma Marcos, Ricard Tokgün, Onur Vales, Gerard Kaya, Bülent |
| Author_xml | – sequence: 1 givenname: Eşref surname: Demir fullname: Demir, Eşref organization: Akdeniz University, Faculty of Sciences, Department of Biology, 07058 Antalya, Turkey – sequence: 2 givenname: Hakan surname: Akça fullname: Akça, Hakan organization: Medical Biology Department, School of Medicine, Pamukkale University, Kinikli, Denizli, Turkey – sequence: 3 givenname: Bülent surname: Kaya fullname: Kaya, Bülent organization: Akdeniz University, Faculty of Sciences, Department of Biology, 07058 Antalya, Turkey – sequence: 4 givenname: Durmuş surname: Burgucu fullname: Burgucu, Durmuş organization: Akdeniz University, Faculty of Medicine, Department of Physiology, 07058 Antalya, Turkey – sequence: 5 givenname: Onur surname: Tokgün fullname: Tokgün, Onur organization: Medical Biology Department, School of Medicine, Pamukkale University, Kinikli, Denizli, Turkey – sequence: 6 givenname: Fatma surname: Turna fullname: Turna, Fatma organization: Akdeniz University, Faculty of Sciences, Department of Biology, 07058 Antalya, Turkey – sequence: 7 givenname: Sezgin surname: Aksakal fullname: Aksakal, Sezgin organization: Akdeniz University, Faculty of Sciences, Department of Biology, 07058 Antalya, Turkey – sequence: 8 givenname: Gerard surname: Vales fullname: Vales, Gerard organization: Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08193 Cerdanyola del Vallès, Spain – sequence: 9 givenname: Amadeu surname: Creus fullname: Creus, Amadeu organization: Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08193 Cerdanyola del Vallès, Spain – sequence: 10 givenname: Ricard surname: Marcos fullname: Marcos, Ricard email: ricard.marcos@uab.es organization: Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Campus de Bellaterra, 08193 Cerdanyola del Vallès, Spain |
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| Keywords | Soft-agar assay ZnO nanoparticles Micronucleus assay Comet assay Genotoxicity UV-light interaction Human Induction Nanoparticle Ultrafine particle In vitro Ultraviolet radiation Aerosols Database Air pollution |
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| Snippet | •Genotoxicity of ZnO NPs has been shown in mammalian cells.•ZnO NPs has been able to induce cell transformation.•An antagonist interaction between ZnO NPs and... The in vitro genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been... |
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| SubjectTerms | Animals Applied sciences Atmospheric pollution Cell Transformation, Neoplastic - chemically induced Comet Assay Exact sciences and technology Genotoxicity HEK293 Cells Humans Mice Micronucleus assay Micronucleus Tests Nanoparticles - radiation effects Nanoparticles - toxicity NIH 3T3 Cells Pollution Soft-agar assay Ultraviolet Rays UV-light interaction Zinc Oxide - radiation effects Zinc Oxide - toxicity ZnO nanoparticles |
| Title | Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential |
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