The inhibitory effects of antimuscarinic autoantibodies in the sera of primary Sjogren syndrome patients on the gastrointestinal motility

•There are antimuscarinic autoantibodies in primary Sjogren syndrome patients’ sera.•SS autoantibodies inhibit muscarinic receptor function in mouse colon and stomach.•The inhibitory effect of SS autoantibodies is mimicked by the 4-DAMP. Impairment of gastrointestinal tract (GI) function, including...

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Bibliographic Details
Published in:	Molecular immunology Vol. 56; no. 4; pp. 583 - 587
Main Authors:	Park, Kyungpyo, Park, Sowon, Jackson, Michael W.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2013
Subjects:	Animals Antibodies Autoantibodies - blood Autoantibodies - immunology Autoantibodies - pharmacology Carbachol (CCh) Carbachol - pharmacology Cholinergic Agonists - pharmacology Colon - drug effects Colon - immunology Colon - physiology Diamines - pharmacology Dose-Response Relationship, Drug Gastrointestinal Motility - drug effects Gastrointestinal Motility - immunology GI dysfunction Humans In Vitro Techniques Male Mice Mice, Inbred BALB C Muscarinic Antagonists - pharmacology Muscarinic receptor Muscle Contraction - drug effects Muscle Contraction - immunology Muscle, Smooth - drug effects Muscle, Smooth - immunology Muscle, Smooth - physiology Piperidines - pharmacology Receptor, Muscarinic M2 - agonists Receptor, Muscarinic M2 - antagonists & inhibitors Receptor, Muscarinic M2 - immunology Receptor, Muscarinic M3 - agonists Receptor, Muscarinic M3 - antagonists & inhibitors Receptor, Muscarinic M3 - immunology Sjogren's Syndrome - blood Sjogren's Syndrome - immunology Sjögren's syndrome (SS) Stomach - drug effects Stomach - immunology Stomach - physiology SS GI Carbachol (CCh) PLC IgG Antibodies CCh CISC M3R 4-DAMP EFS NK1 GI dysfunction Sjögren's syndrome (SS) SM Muscarinic receptor gastrointestinal tract smooth muscle muscarinic receptor type 3 phospholipase C immunoglobulin G neurokinin 1 1,1-dimethyl-4-diphenyl acetoxy piperidinium iodide Carbachol Sjögren's syndrome carbachol-induced smooth muscle contraction electrical field stimulation
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