Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells

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Published in:	Molecular and Cellular Biology Vol. 13; no. 6; pp. 3722 - 3733
Main Authors:	GORSKI, D. H, LEPAGE, D. F, PATEL, C. V, COPELAND, N. G, JENKINS, N. A, WALSH, K
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-06-1993
Subjects:	Animals Aorta - cytology Aorta - physiology Base Sequence Biological and medical sciences Cell Cycle - physiology Chromosome Mapping Cloning, Molecular Crosses, Genetic DNA - genetics DNA - isolation & purification Female Fundamental and applied biological sciences. Psychology G1 Phase Gene Library Genes, Homeobox - drug effects Genes. Genome Genetic Variation Homeodomain Proteins Humans Kinetics Male Mice Mice, Inbred C57BL Molecular and cellular biology Molecular genetics Molecular Sequence Data Muridae Muscle Proteins - genetics Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Oligodeoxyribonucleotides Platelet-Derived Growth Factor - pharmacology Rats Resting Phase, Cell Cycle Sequence Homology, Amino Acid Thymidine - metabolism Vertebrata Mammalia Rat Blood vessel Rodentia Cell cycle Homeotic gene Smooth muscle Gene organization Primary structure Gene expression Phase transitions
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Abstract	Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB
AbstractList	Adult vascular smooth muscle cells dedifferentiate and reenter the cell cycle in response to growth factor stimulation. Here we describe the molecular cloning from vascular smooth muscle, the structure, and the chromosomal location of a diverged homeobox gene, Gax, whose expression is largely confined to the cardiovascular tissues of the adult. In quiescent adult rat vascular smooth muscle cells, Gax mRNA levels are down-regulated as much as 15-fold within 2 h when these cells are induced to proliferate with platelet-derived growth factor (PDGF) or serum growth factors. This reduction in Gax mRNA is transient, with levels beginning to rise between 8 and 24 h after mitogen stimulation and returning to near normal by 24 to 48 h. The Gax down-regulation is dose dependent and can be correlated with the mitogen's ability to stimulate DNA synthesis. PDGF-AA, a weak mitogen for rat vascular smooth muscle cells, did not affect Gax transcript levels, while PDGF-AB and -BB, potent mitogens for these cells, were nearly as effective as fetal bovine serum. The removal of serum from growing cells induced Gax expression fivefold within 24 h. These data suggest that Gax is likely to have a regulatory function in the G0-to-G1 transition of the cell cycle in vascular smooth muscle cells. Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MCB .asm.org, visit: MCB
Author	D F LePage N G Copeland K Walsh N A Jenkins C V Patel D H Gorski
AuthorAffiliation	Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
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Keywords	Vertebrata Mammalia Rat Blood vessel Rodentia Cell cycle Homeotic gene Smooth muscle Gene organization Primary structure Gene expression Phase transitions
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Snippet	Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... Adult vascular smooth muscle cells dedifferentiate and reenter the cell cycle in response to growth factor stimulation. Here we describe the molecular cloning...
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SubjectTerms	Animals Aorta - cytology Aorta - physiology Base Sequence Biological and medical sciences Cell Cycle - physiology Chromosome Mapping Cloning, Molecular Crosses, Genetic DNA - genetics DNA - isolation & purification Female Fundamental and applied biological sciences. Psychology G1 Phase Gene Library Genes, Homeobox - drug effects Genes. Genome Genetic Variation Homeodomain Proteins Humans Kinetics Male Mice Mice, Inbred C57BL Molecular and cellular biology Molecular genetics Molecular Sequence Data Muridae Muscle Proteins - genetics Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Oligodeoxyribonucleotides Platelet-Derived Growth Factor - pharmacology Rats Resting Phase, Cell Cycle Sequence Homology, Amino Acid Thymidine - metabolism
Title	Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells
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