Development of a liquid–liquid extraction procedure for five 1,4-dihydropyridines calcium channel antagonists from human plasma using experimental design

A liquid–liquid extraction method using diethyl ether as organic solvent was optimized simultaneously for five 1,4-dihydropyridines (amlodipine, nitrendipine, felodipine, lacidipine and lercanidipine) belonging to the group of calcium channel blockers. Some experimental tools such as a full factoria...

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Bibliographic Details
Published in:	Talanta (Oxford) Vol. 67; no. 5; pp. 933 - 941
Main Authors:	Baranda, A.B., Etxebarria, N., Jiménez, R.M., Alonso, R.M.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 31-10-2005 Oxford Elsevier
Subjects:	1,4-Dihydropyiridines Analytical chemistry Calcium channel antagonists Chemistry Chromatographic methods and physical methods associated with chromatography Exact sciences and technology LLE Other chromatographic methods Plasma and method optimization Plasma and method optimization Calcium channel antagonists LLE 1,4-Dihydropyiridines Water Calcium HPLC chromatography Mobile phase Optimization Chemical enrichment Sample preparation Diode array Antagonist Quantitative analysis Human Ether Liquid liquid extraction Extraction process Acetate Organic solvent Experimental design Reproducibility Acetonitrile Amlodipine Factorial design Sensor array
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