The making of filopodia

Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments. They are found on a variety of cell types and have been ascribed sensory or exploratory functions. Filopodium formation is frequently associated with protrusion of sheet-like actin filament arrays called...

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Bibliographic Details
Published in:	Current opinion in cell biology Vol. 18; no. 1; pp. 18 - 25
Main Authors:	Faix, Jan, Rottner, Klemens
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2006
Subjects:	Animals Dictyostelium - metabolism Mice Microfilament Proteins - chemistry Microfilament Proteins - metabolism Models, Biological Pseudopodia - chemistry Pseudopodia - metabolism Pseudopodia - ultrastructure Signal Transduction
Online Access:	Get full text
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Summary:	Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments. They are found on a variety of cell types and have been ascribed sensory or exploratory functions. Filopodium formation is frequently associated with protrusion of sheet-like actin filament arrays called lamellipodia and membrane ruffles, but, in comparison to these structures, the molecular details underpinning the initiation and maintenance of filopodia are only just beginning to emerge. Recent advances have improved our understanding of the molecular requirements for filopodium protrusion and have yielded insights into the inter-relationships between lamellipodia and filopodia, the two ‘sub-compartments’ of the protrusive actin cytoskeleton.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2005.11.002