Antitumour effects on human colorectal carcinomas cells by stable silencing of phospholipase C-gamma 1 with lentivirus-delivered siRNA

In most colorectal carcinomas, the level of phospholipase C (PLC)-gamma 1 expression is greatly elevated. Increased expression of PLC-gamma 1 may play an important role in colon carcinogenesis, but the mechanism is not well known. The aim of this study was to evaluate the role of PLC-gamma 1 in colo...

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Bibliographic Details
Published in:	Chinese medical journal Vol. 120; no. 9; pp. 749 - 754
Main Authors:	Tan, Li, Xiao, Bing-xiang, Zeng, Wei-sen, Lin, Jun, Zou, Zhi-peng, Xu, Ai-min, Luo, Shen-qiu
Format:	Journal Article
Language:	English
Published:	China Department of Cell Biology, Southern Medical University, Guangzhou 510515, China%Department of Cell Biology,Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China%Graduate School of Medicine, Hong Kong University, Hong Kong 999077, China 05-05-2007
Subjects:	Apoptosis - drug effects Cell Adhesion Cell Line, Tumor Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Fluorouracil - pharmacology Humans Laminin - antagonists & inhibitors Laminin - genetics Lentivirus - genetics Phospholipase C gamma - antagonists & inhibitors Phospholipase C gamma - genetics Phospholipase C gamma - physiology RNA, Small Interfering - therapeutic use migration apoptosis siRNA adhesion phospholipase C gamma lentivirus
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