Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα

Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the role of IL-15/IL-15Rα in the pathogenesis of T1D, we generated double transgenic mice with pancreatic β-cell expression of IL-15 and IL-15Rα. T...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 33; pp. 13534 - 13539
Main Authors:	Chen, Jing, Feigenbaum, Lionel, Awasthi, Parirokh, Butcher, Donna O., Anver, Miriam R., Golubeva, Yelena G., Bamford, Richard, Zhang, Xiaojie, St. Claire, Mark B., Thomas, Craig J., Discepolo, Valentina, Jabri, Bana, Waldmann, Thomas A.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 13-08-2013 National Acad Sciences
Subjects:	Animals Beta cells Biological Sciences Blood glucose Diabetes Diabetes Mellitus, Type 1 - etiology Disease Models, Animal Humans Hyperglycemia Insulin-Secreting Cells - metabolism Interleukin-15 - antagonists & inhibitors Interleukin-15 - blood Interleukin-15 - metabolism Interleukin-15 Receptor alpha Subunit - blood Interleukin-15 Receptor alpha Subunit - metabolism Islet cells Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Transgenic Natural killer cells Piperidines - pharmacology Pyrimidines - pharmacology Pyrroles - pharmacology Signal Transduction - drug effects T lymphocytes Transgenic animals Type 1 diabetes mellitus
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