Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase

In the search for a pharmacological answer to treat Chagas disease, eight metal complexes with two bioactive bisphosphonates, alendronate (Ale) and pamidronate (Pam), were described. Complexes of the formula [M(2)(II)(Ale)(4)(H(2)O)(2)]·2H(2)O, with M = Cu, Co, Mn, Ni, and ([CuPam]·H(2)O)(n) as well...

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Bibliographic Details
Published in:	Dalton transactions : an international journal of inorganic chemistry Vol. 41; no. 21; p. 6468
Main Authors:	Demoro, Bruno, Caruso, Francesco, Rossi, Miriam, Benítez, Diego, González, Mercedes, Cerecetto, Hugo, Galizzi, Melina, Malayil, Leena, Docampo, Roberto, Faccio, Ricardo, Mombrú, Alvaro W, Gambino, Dinorah, Otero, Lucía
Format:	Journal Article
Language:	English
Published:	England 07-06-2012
Subjects:	Animals Cell Proliferation - drug effects Cercopithecus aethiops Diphosphonates - chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Geranyltranstransferase - antagonists & inhibitors Humans Inhibitory Concentration 50 Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - metabolism Organometallic Compounds - pharmacology Serum Albumin, Bovine - metabolism Trypanosoma cruzi - cytology Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Vero Cells
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