Stability of cidofovir in 0.9% sodium chloride injection and in 5% dextrose injection

• Published in: American journal of health-system pharmacy Vol. 53; no. 16; pp. 1939 - 1943
• Main Authors: Yuan, LC, Samuels, GJ, Visor, GC
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASHP 15-08-1996; American Society of Health Pharmacists
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - chemistry; Biological and medical sciences; Chromatography, High Pressure Liquid; Cidofovir; Cytosine - analogs & derivatives; Cytosine - chemistry; Drug Stability; Glucose; Hydrogen-Ion Concentration; Injections; Medical sciences; Organophosphonates; Organophosphorus Compounds - chemistry; Osmolar Concentration; Particle Size; Pharmacology. Drug treatments; Polyvinyl Chloride; Sodium Chloride; Time Factors; Polyethylene; Acyclic nucleoside; Drug adjuvant interaction; Stability; Intravenous administration; Propylene polymer; Conservation; Vehicle(excipient); Container content interaction; Sodium chloride; Chlorinated ethylene polymer; Parenteral form; Antiviral; Pyrimidine nucleotide; Physicochemical properties
• ISSN: 1079-2082; 1535-2900
• DOI: 10.1093/ajhp/53.16.1939

The stability of cidofovir in i.v. admixtures under refrigerator and room temperature conditions was studied. Admixtures of cidofovir 0.21 and 8.12 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection and of 0.085 and 3.51 mg/mL in 5% dextrose and 0.45% sodium chloride injection were prepared in triplicate in polyvinyl chloride (PVC) or polyethylene-polypropylene containers and i.v. administration sets and stored for 24 hours at 2-8 or 30 degrees C. The lower concentration of cidofovir corresponded to an assumed dose of 0.5 mg/kg for a 40-kg patient, and the higher concentration to an assumed dose of 10 mg/kg for a 100-kg patient. Samples were removed at 0 and 24 hours and analyzed for cidofovir concentration by high-performance liquid chromatography. Physical compatibility was also studied. The stability of cidofovir in 0.9% sodium chloride injection and in 5% dextrose injection at low- and high-dose concentrations was unaffected by storage at either temperature. All admixtures were clear, colorless, and free of visible particles or precipitation. There were no substantial changes in pH or number of particles of > or = 10 microns in diameter. Cidofovir 0.21 and 0.12 mg/mL was stable in 0.9% sodium chloride injection and 5% dextrose injection in PVC and polyethylene-polypropylene containers and i.v. administration sets for up to 24 hours at 2-8 and 30 degrees C. Cidofovir was compatible with the injectable solutions studied.