Effect of Peptides of the Insulin Superfamily on Glucose-6-Phosphate Dehydrogenase Activity in Skeletal Muscles of River Lamprey (Lampetra fluviatilis) during Prespawning Starvation

• Published in: Bulletin of experimental biology and medicine Vol. 148; no. 1; pp. 29 - 32
• Main Authors: Chistyakova, O. V, Kuznetsova, L. A
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01-07-2009; Springer US; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Breeding; Cell Biology; glucose-6-phosphate 1-dehydrogenase; Glucosephosphate Dehydrogenase - metabolism; insulin; Insulin - chemistry; Insulin - pharmacology; insulin-like growth factor 1; Internal Medicine; Laboratory Medicine; lamprey; Lampreys - physiology; Muscle, Skeletal - drug effects; Muscle, Skeletal - enzymology; Pathology; Peptide Fragments - pharmacology; relaxin; Starvation; glucose-6-phosphate dehydrogenase; relaxin; insulin; insulin-like growth factor 1; lamprey
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0632-x

Glucose-6-phosphate dehydrogenase activity in skeletal muscles of the lamprey (Lampetra fluviatilis) decreased during prespawning starvation (September-May). The observed changes were particularly pronounced in January. Insulin, insulin-like growth factor 1, and relaxin produce an in vitro stimulatory effect on the enzyme. Insulin was most potent in this respect. Inactivation of the enzyme was accompanied by a decrease in its sensitivity to the stimulatory effect of insulin and insulin-like growth factor 1.