Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats

Changes in urinary porphyrin excretion patterns (porphyrin profiles) during prolonged mercury exposure are attributable to mercury accumulation in the kidney and to consequent effects of Hg2+ on renal porphyrin metabolism. In the present study, we evaluated the quantitative relationship of urinary p...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 61; no. 2; pp. 234 - 240
Main Authors:	PINGREE, Stephanie D, LYNNE SIMMONDS, P, RUMMEL, Kevin T, WOODS, James S
Format:	Journal Article
Language:	English
Published:	Cary, NC Oxford University Press 01-06-2001
Subjects:	Animals Biological and medical sciences Body Burden Chelating Agents - therapeutic use Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Kidney - metabolism Linear Models Male Medical sciences Mercury - metabolism Mercury - urine Mercury Poisoning - urine Metals and various inorganic compounds Methylmercury Compounds - poisoning Porphyrins - urine Rats Rats, Inbred F344 Regression Analysis Spectrometry, Fluorescence Statistics as Topic Time Factors Tissue Distribution Toxicology Unithiol - administration & dosage Unithiol - therapeutic use Biological fluid Intraperitoneal administration Chemical analysis Rat Biological marker Mercaptoacid Kidney Tissue Mercury Organic compounds Quantitative analysis Urine Rodentia Elimination Oral administration Sulfonic acid Heavy metal Toxicokinetics Vertebrata Mammalia Correlation analysis Porphyrin Animal Distribution Chelating agent Kinetics
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