Urease inhibitory potential of extracts and active phytochemicals of Hypochaeris radicata (Asteraceae)
Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for thei...
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| Published in: | Natural product research Vol. 34; no. 4; pp. 553 - 557 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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Taylor & Francis
16-02-2020
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| Abstract | Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC
50
value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 µM respectively. The compounds (1-4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 µM) of urease enzyme. |
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| AbstractList | Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1-4). On evaluation, compounds (1-4) exhibited selective activity against urease enzyme with an IC
50
value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 µM respectively. The compounds (1-4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 µM) of urease enzyme. Urease inhibition potential of compound (1), guaiane-type sesquiterpene (2), confertin (3) and scopoletin (4) was carried out with high throughout mechanism-based assay. These compounds were isolated from Hypochaeris radicata L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds (1–4). On evaluation, compounds (1–4) exhibited selective activity against urease enzyme with an IC50 value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 µM respectively. The compounds (1–4) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 µM) of urease enzyme. Urease inhibition potential of compound ( ), guaiane-type sesquiterpene ( ), confertin ( ) and scopoletin ( ) was carried out with high throughout mechanism-based assay. These compounds were isolated from L., an Asteraceae family member. The pure compounds were screened for their urease and carbonic anhydrase inhibitory activities. The ethyl acetate fractions were subjected to column chromatography, which resulted in the isolation and purification of four compounds ( ). On evaluation, compounds ( ) exhibited selective activity against urease enzyme with an IC value of 180.11 ± 2.00, 27.18 ± 0.80, 24.12 ± 0.2 and 30.12 ± 1.10 µM respectively. The compounds ( ) were found to be inactive against carbonic anhydrase enzyme. Thiourea was used as standard inhibitor (21 ± 0.14 µM) of urease enzyme. |
| Author | Abu-Izneid, Tareq Patel, Seema Abdelhady, Mohamed I. S. Saleem, Muhammad Ibrahim, Munjed M. Mansour, Nashwa Rauf, Abdur |
| Author_xml | – sequence: 1 givenname: Tareq surname: Abu-Izneid fullname: Abu-Izneid, Tareq email: tmabuzneid@uqu.edu.sa, mashaljcs@yahoo.com organization: Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of Science and Technology – sequence: 2 givenname: Abdur surname: Rauf fullname: Rauf, Abdur organization: Department of Chemistry, University of Swabi – sequence: 3 givenname: Muhammad surname: Saleem fullname: Saleem, Muhammad organization: Department of Chemistry, University of Education, Lahore – sequence: 4 givenname: Nashwa surname: Mansour fullname: Mansour, Nashwa organization: Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suief University – sequence: 5 givenname: Mohamed I. S. surname: Abdelhady fullname: Abdelhady, Mohamed I. S. organization: Department of Pharmacognosy, Faculty of Pharmacy, Helwan University – sequence: 6 givenname: Munjed M. surname: Ibrahim fullname: Ibrahim, Munjed M. organization: Faculty of Pharmacy, Umm Al-Qura University – sequence: 7 givenname: Seema surname: Patel fullname: Patel, Seema organization: Bioinformatics and Medical Informatics Research Center, San Diego State University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30317858$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1080/07352689.2011.616039 10.1016/j.cbpa.2010.06.161 10.1007/978-3-642-32653-0_1 10.1016/j.indcrop.2015.03.039 10.12980/APJTB.4.2014C1030 10.1093/jpe/rtu032 10.1080/14786419.2016.1226832 10.1016/j.tips.2006.09.002 10.1007/s13205-011-0007-7 10.1016/j.toxicon.2013.04.023 10.1089/dna.2007.0599 10.1016/0031-9422(94)00792-R 10.1155/2016/5429625 10.3732/ajb.93.2.234 10.1074/jbc.R100045200 10.3390/molecules21040496 |
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| Keywords | phytochemicals Hypochaeris radicata urease inhibition Carbonic cnhydrase inhibition |
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| SubjectTerms | Acetic acid Asteraceae Asteraceae - chemistry Carbonic anhydrase Carbonic anhydrases Carbonic cnhydrase inhibition Column chromatography Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Enzymes Ethyl acetate Hypochaeris radicata Phytochemicals Phytochemicals - analysis Phytochemicals - isolation & purification Phytochemicals - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Purification Sesquiterpenes - analysis Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Thiourea Urease Urease - antagonists & inhibitors urease inhibition |
| Title | Urease inhibitory potential of extracts and active phytochemicals of Hypochaeris radicata (Asteraceae) |
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