BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT

BAFF is a peripheral B cell survival factor and can mediate antibody (Ab) class switching. Over-expression of BAFF in mice results in B cell hyperplasia, elevated serum immunoglobulin (Ig), spontaneous germinal centre (GC) reactions and mild glomerulonephritis (GN). Here we show that, in addition to...

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Bibliographic Details
Published in:	Cellular Immunology Vol. 241; no. 2; pp. 85 - 94
Main Authors:	McCarthy, Douglas D., Chiu, Sidney, Gao, Yunfei, Summers-deLuca, Leslie E., Gommerman, Jennifer L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-06-2006
Subjects:	Aging - immunology Animals Autoantibodies - immunology B cell B-Cell Activation Factor Receptor - metabolism B-Lymphocytes - cytology BAFF Germinal Center - immunology Glomerulonephritis Hyperplasia - immunology IgA Immunoglobulin A - blood Immunoglobulin A - immunology Intestine, Small - cytology Intestine, Small - pathology Kidney Kidney - cytology Kidney - immunology Kidney - pathology Lamina propria LIGHT Lymphotoxin beta Receptor - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Mucous Membrane - cytology Mucous Membrane - pathology Nephritis Phenotype Signal Transduction Syndrome Tumor Necrosis Factor Ligand Superfamily Member 14 - deficiency Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Glomerulonephritis BAFF B cell IgA Nephritis LIGHT Lamina propria Kidney
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