1,25-dihydroxyvitamin D3 prevents deleterious effects of homocysteine on mitochondrial function and redox status in heart slices

Abstract Since homocysteine (Hcy) is a risk factor for cardiovascular disease and vitamin D deficiency can contribute to cardiovascular pathologies, in the present study we tested the hypothesis that Hcy could impair energy metabolism, mitochondrial function and redox status in heart slices of Wista...

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Bibliographic Details
Published in:	Nutrition research (New York, N.Y.) Vol. 38; pp. 52 - 63
Main Authors:	Longoni, Aline, Kolling, Janaina, Siebert, Cassiana, dos Santos, João Paulo, da Silva, Jussemara Souza, Pettenuzzo, Letícia F, Meira-Martins, Leo Anderson, Gonçalves, Carlos-Alberto, de Assis, Adriano M, Wyse, Angela TS
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-02-2017
Subjects:	Calcitriol Energy metabolism Gastroenterology and Hepatology Heart slices Homocysteine Mitochondria function Redox status hyperhomocysteinemia MTG DMSO dimethylsulfoxide MTR DA2′,7′-dihydrodichlorofluorescein diacetate 2,4-dinitrophenylhydrazine SDH RNS vitamin D receptor energy metabolism catalase DCFH Glutathione peroxidase cytrochome c oxidase DNPH TBARS 2-nitrobenzoic acid GPx reactive species nitrogen TCA MitoTracker Red CMXRos calcitriol superoxide dismutase ROS CAT 2,6-dichloroindophenol Hcy trichloroacetic acid NADPH henazinemethosulfate redox status Thiobarbituric acid reactive species Mito-Tracker Green FM propidium iodide reactive oxygen species HHcy heart slices DTNB VDR 2′,7′-Dihydrodichlorofluorescein SOD COX succinate dehydrogenase mitochondria function Nicotinamide adenine dinucleotide phosphate PMS DCIP PI Homocysteine Energy metabolism Calcitriol Mitochondria function Heart slices Redox status
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