The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse

• Published in: Climacteric : the journal of the International Menopause Society Vol. 25; no. 4; pp. 407 - 412
• Main Authors: Costa e Silva, C. L., Bortolini, M. A. T., Batista, N. C., Silva, R. S. P., Teixeira, J. B., Oliveira, É., Souto, R. P., Castro, R. A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04-07-2022; Taylor & Francis Ltd
• Subjects: elastic fibers; elastin; extracellular matrix; lysyl oxidase-like 1; Pelvic organ prolapse; Polymorphism; elastic fibers; Pelvic organ prolapse; polymorphism; lysyl oxidase-like 1; elastin; extracellular matrix
• ISSN: 1369-7137; 1473-0804
• DOI: 10.1080/13697137.2022.2058392

This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (Loxl1) gene and its association with pelvic organ prolapse (POP) in Brazilian women and determine risk factors for POP development.
The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with p < 0.05 for significance.
A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42).
No association was detected between rs2165241 of the Loxl1 gene and POP.