Effects of Obesity on the Regulation of Macrophage Population in the Prostate Tumor Microenvironment

Obesity is associated with a greater risk of prostate cancer mortality. However, the mechanisms connecting obesity to the progression of prostate cancer remain unknown. This study determined the impact of obesity on macrophage recruitment and tumor-associated macrophage (TAM) polarization in the pro...

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Bibliographic Details
Published in:	Nutrition and cancer Vol. 69; no. 7; pp. 996 - 1002
Main Authors:	Galván, G. C., Johnson, C. B., Price, R. S., Liss, M. A., Jolly, C. A., deGraffenried, L. A.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 03-10-2017 Taylor & Francis Ltd
Subjects:	Adipocytes Animals Arginase Cancer Cell Line, Tumor Chemokine CCL2 - genetics Conditioning Cyclooxygenase 2 - genetics Cyclooxygenase-2 Dinoprostone - metabolism Enzyme-linked immunosorbent assay Epithelial Cells - metabolism Epithelial Cells - pathology Gelatinase B Health risks Humans Infiltration Interleukin 10 Macrophages Macrophages - metabolism Macrophages - pathology Male Markers Metastases Mice, Inbred C57BL Mice, Obese Monocyte chemoattractant protein 1 mRNA Obesity Obesity - complications Obesity - pathology Paracrine Communication Polarization Prostaglandin E2 Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Transforming growth factor-b Tumor Microenvironment Tumors Vascular endothelial growth factor
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