Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial

• Published in: Annals of surgery Vol. 275; no. 3; pp. 448 - 455
• Main Authors: Onerup, Aron, Andersson, John, Angenete, Eva, Bock, David, Börjesson, Mats, Ehrencrona, Carolina, Fagevik Olsén, Monika, Larsson, Per-Anders, de la Croix, Hanna, Wedin, Anette, Haglind, Eva
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01-03-2022
• Subjects: Aged; Aged, 80 and over; Colorectal Neoplasms - surgery; Diagnostic Self Evaluation; Exercise; Female; Humans; Idrottsvetenskap; Kirurgi; Male; Middle Aged; Postoperative Care; Preoperative Exercise; Randomized Controlled Trials; Recovery of Function; Sport and Fitness Sciences; Surgery; Time Factors
• DOI: 10.1097/SLA.0000000000004901
• EISSN: 1528-1140
• ISSN: 0003-4932; 1528-1140

To determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery.
Preoperative exercise interventions could help improve recovery after colorectal cancer surgery and is currently recommended.
A randomized, parallel, open-label trial in six university or regional hospitals in Sweden. Inclusion criteria were age ≥20 years and planned elective colorectal cancer surgery. Participants were randomized to either a physical activity intervention with aerobic activity and inspiratory muscle training 2 weeks pre- and 4 weeks postoperatively or usual care. The primary outcome measure was self-assessed physical recovery 4 weeks postoperatively. Analyses were performed according to intention to treat. Outcome assessors were masked regarding the intervention while both participants and physiotherapists were informed due to the nature of the intervention.
Between January 22, 2015, and May 28, 2020, 761 participants were recruited and assigned to either intervention (I) (n = 379) or control (C) (n = 382). After exclusions 668 participants (I = 317, C = 351) were included in the primary analysis. There was no effect from the intervention on the primary outcome measure (adjusted odds ratio 0.84, 95% confidence interval 0.62-1.15) with 13% and 15% of participants feeling fully physically recovered in I and C, respectively. There were no reported adverse events.
There was no effect from a physical activity intervention before and after colorectal cancer surgery on short-term self-assessed physical recovery. The results from this study call for reconsiderations regarding current recommendations for preoperative physical activity interventions.