Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR‐Preserved Trial

Background The principal biological processes that characterize heart failure with a preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue accumulation, coronary microcirculatory rarefaction, myocardial fibrosis and vascular stiffness; the resulting impairment of l...

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Published in:	European journal of heart failure Vol. 21; no. 10; pp. 1279 - 1287
Main Authors:	Anker, Stefan D., Butler, Javed, Filippatos, Gerasimos S., Jamal, Waheed, Salsali, Afshin, Schnee, Janet, Kimura, Karen, Zeller, Cordula, George, Jyothis, Brueckmann, Martina, Zannad, Faiez, Packer, Milton, Perrone, Sergio, Nicholls, Stephen, Janssens, Stefan, Bocchi, Edmar, Giannetti, Nadia, Verma, Subodh, Jian, Zhang, Gomez Mesa, Juan Esteban, Spinar, Jindrich, Böhm, Michael, Merkely, Bela, Chopra, Vijay, Senni, Michele, Taddi, Stefano, Tsutsui, Hiroyuki, Chuquiure, Eduardo, La Rocca, Hans Pieter Brunner, Ponikowski, Piotr, Vinereanu, Dragos, Sim, David, Choi, Dong‐Ju, Juanatey, Jose Ramon Gonzalez, Squire, Iain, Januzzi, James, Pina, Ileana, Pocock, Stuart J., Carson, Peter, Doehner, Wolfram, Miller, Alan, Haas, Markus, Pehrson, Steen, Komajda, Michel, Anand, Inder, Teerlink, John, Rabinstein, Alejandro, Steiner, Thorsten, Kamel, Hooman, Tsivgoulis, Georgios, Lewis, James, Freston, James, Kaplowitz, Neil, Mann, Johannes, Petrie, Mark, Bernstein, Richard, Cheung, Alfred, Green, Jennifer, Kaul, Sanjay, Ping, Carolyn Lam Su, Lip, Gregory, Marx, Nikolaus, McCullough, Peter, Mehta, Cyrus, Rosenstock, Julio, Sattar, Naveed, Scirica, Benjamin, Wanner, Christoph, Welty, Francine K., Parhofer, Klaus G., Clayton, Tim, Pedersen, Terje R., Lees, Kennedy R., Konstam, Marvin A., Greenberg, Barry, Palmer, Mike
Format:	Journal Article
Language:	English
Published:	Oxford, UK John Wiley & Sons, Ltd 01-10-2019 European Society of Cardiology (Wiley)
Subjects:	Cardiology and cardiovascular system Diabetes Heart failure Human health and pathology Life Sciences SGLT2 inhibitors Trial design Heart failure Diabetes Trial design SGLT2 inhibitors
Online Access:	Get full text
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