Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus
Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typ...
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| Published in: | Acta histochemica Vol. 113; no. 2; pp. 109 - 116 |
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| Abstract | Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6 (33%) were HPV 6/11, 1 (5%) was HPV 16, 14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopostivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopostivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4 (22%) out of 18 potential malignant epithelial lesions (PMEL) and 11 (57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B. |
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| AbstractList | Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6 (33%) were HPV 6/11, 1 (5%) was HPV 16, 14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopostivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopostivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4 (22%) out of 18 potential malignant epithelial lesions (PMEL) and 11 (57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B. Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between the expression of p27, mdm2 and cathepsin B and by HPV-related oral lesions. Fifty-five oral biopsies were studied and HPV detection and typing (6/11, 16, 18, 31 and 33) were performed using polymerase chain reaction techniques. The distribution p27, mdm2 and cathepsin B was determined by immunohistochemistry. Twenty-one (38%) out of the 55 oral lesions tested positive for HPV, of which 6 (33%) were HPV 6/11, 1 (5%) was HPV 16, 14 (72%) were HPV 18 and none was HPV 33/31. Among the 55 biopsies, immunopositivity for p27, mdm2 and cathepsin B was observed in 17 (30.9%), 37 (67.2%) and 37 (67.2%), respectively. Among 21 HPV-positive oral lesions, immunopositivity of mdm2, p27 and cathepsin B was found, respectively, in 6 (33%) out of 18 benign lesions (BL), 4 (22%) out of 18 potential malignant epithelial lesions (PMEL) and 11 (57.9%) out of 19 malignant lesions (ML). High-risk HPV types may be associated with oral carcinoma, by cell-cycle control dysregulation, contributing to oral carcinogenesis and the overexpression of mdm2, p27 and cathepsin B. |
| Author | Garcia Soares, Edson Antonio Donadi, Eduardo Guimarães Gonçalves, Maria Alice Patrícia Klay, Carla Resende, Luis Tersariol, Ivarne Cristina Mazon, Renata Aparecida Pinhal, Maria Pienna Soares, Christiane Benatti Neto, Carlos de Oliveira, Maria Rita Brancini Rovigatti Gerbelli, Thaís |
| Author_xml | – sequence: 1 givenname: Renata surname: Cristina Mazon fullname: Cristina Mazon, Renata organization: School of Pharmaceutical Sciences, UNESP – São Paulo State University, São Paulo, Brazil – sequence: 2 givenname: Thaís surname: Rovigatti Gerbelli fullname: Rovigatti Gerbelli, Thaís organization: School of Pharmaceutical Sciences, UNESP – São Paulo State University, São Paulo, Brazil – sequence: 3 givenname: Carlos surname: Benatti Neto fullname: Benatti Neto, Carlos organization: School of Dentistry, UNESP – São Paulo State University, São Paulo, Brazil – sequence: 4 givenname: Maria Rita Brancini surname: de Oliveira fullname: de Oliveira, Maria Rita Brancini organization: School of Dentistry, UNESP – São Paulo State University, São Paulo, Brazil – sequence: 5 givenname: Eduardo surname: Antonio Donadi fullname: Antonio Donadi, Eduardo organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 6 givenname: Maria Alice surname: Guimarães Gonçalves fullname: Guimarães Gonçalves, Maria Alice organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 7 givenname: Edson surname: Garcia Soares fullname: Garcia Soares, Edson organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 8 givenname: Carla surname: Patrícia Klay fullname: Patrícia Klay, Carla organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 9 givenname: Ivarne surname: Tersariol fullname: Tersariol, Ivarne organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 10 givenname: Maria surname: Aparecida Pinhal fullname: Aparecida Pinhal, Maria organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 11 givenname: Luis surname: Resende fullname: Resende, Luis organization: Faculty of Medicine, Federal University of São Paulo State (UNIFESP), São Paulo, Brazil – sequence: 12 givenname: Christiane surname: Pienna Soares fullname: Pienna Soares, Christiane email: soarescp@hotmail.com organization: School of Pharmaceutical Sciences, UNESP – São Paulo State University, São Paulo, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19811804$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s10006_012_0383_0 crossref_primary_10_1111_jop_12268 crossref_primary_10_4236_abb_2014_57072 crossref_primary_10_1590_S1678_77572011005000013 crossref_primary_10_4103_JDRNTRUHS_JDRNTRUHS_54_19 crossref_primary_10_1016_j_biopha_2023_115035 crossref_primary_10_1016_j_archoralbio_2015_11_017 crossref_primary_10_1007_s00404_012_2665_z crossref_primary_10_1016_j_bjorl_2015_04_001 |
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| Keywords | Immunohistochemistry Cathepsin B Oral cancer p27 HPV mdm2 |
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| Snippet | Since the role of human papillomavirus (HPV) infection in oral carcinogenesis is still unclear, the purpose of this study was to verify the association between... |
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| SubjectTerms | Benign Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - virology Cathepsin B Cathepsin B - analysis Cathepsin B - biosynthesis Cathepsin B - genetics Cell Cycle - genetics Cyclin-Dependent Kinase Inhibitor p27 - analysis Cyclin-Dependent Kinase Inhibitor p27 - biosynthesis Cyclin-Dependent Kinase Inhibitor p27 - genetics HPV Human papillomavirus Humans Immunohistochemistry mdm2 Mouth Neoplasms - genetics Mouth Neoplasms - virology Oral cancer p27 Papillomavirus Infections - complications Papillomavirus Infections - genetics Proto-Oncogene Proteins c-mdm2 - analysis Proto-Oncogene Proteins c-mdm2 - biosynthesis Proto-Oncogene Proteins c-mdm2 - genetics Reverse Transcriptase Polymerase Chain Reaction |
| Title | Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus |
| URI | https://dx.doi.org/10.1016/j.acthis.2009.08.008 https://www.ncbi.nlm.nih.gov/pubmed/19811804 https://search.proquest.com/docview/911150629 |
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