TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma

A diagnostic dilemma can be encountered when primary triple-negative breast carcinoma (TNBC) without an in situ component or metastatic TNBCs lose the currently used organ-specific marker such as GATA3, raising concerns about metastatic carcinoma from other sites. In the current study, we compared t...

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Published in:	Human pathology Vol. 125; pp. 97 - 107
Main Authors:	Yoon, Esther C., Wang, Gang, Parkinson, Bryce, Huo, Lei, Peng, Yan, Wang, Jing, Salisbury, Taylor, Wu, Yun, Chen, Hui, Albarracin, Constance T., Resetkova, Erika, Middleton, Lavinia P., Krishnamurthy, Savitri, Gan, Qiong, Sun, Hongxia, Huang, Xiao, Shen, Tiansheng, Chen, Wei, Parwani, Anil V., Sahin, Aysegul A., Li, Zaibo, Ding, Qingqing
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2022 Elsevier Limited
Subjects:	Breast cancer GATA3 Invasive breast carcinoma of no special type Invasive lobular carcinoma Melanoma Metaplastic carcinoma Metastasis Monoclonal antibodies SOX10 Stains & staining Triple-negative breast carcinoma TRPS1 Tumors Invasive breast carcinoma of no special type Metaplastic carcinoma Triple-negative breast carcinoma TRPS1 GATA3 SOX10 Invasive lobular carcinoma
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Abstract	A diagnostic dilemma can be encountered when primary triple-negative breast carcinoma (TNBC) without an in situ component or metastatic TNBCs lose the currently used organ-specific marker such as GATA3, raising concerns about metastatic carcinoma from other sites. In the current study, we compared the newly identified breast marker TRPS1 with currently used breast markers GATA3 and SOX10 in whole-tissue sections from 315 cases of various subtypes of TNBC. TRPS1 was highly expressed in 100% of triple-negative primary and metastatic invasive lobular carcinomas, 99% of triple-negative primary and metastatic invasive breast carcinoma of no special type (IBC-NST), and 95% of metaplastic breast carcinomas. In contrast, GATA3 and SOX10 were expressed in 94% and 0% of invasive lobular carcinomas, 63% and 74% of IBC-NST, and 50% and 49% of metaplastic breast carcinomas, respectively. For special-type TNBCs, both TRPS1 and GATA3 were negative in acinic cell carcinomas, most cribriform adenoid cystic carcinomas, and neuroendocrine carcinomas, but positive in secretory carcinomas. Triple-negative apocrine carcinoma was the only subtype of TNBC with positive GATA3 but negative TRPS1. These data indicate that TRPS1 is a highly sensitive marker for TNBCs with positivity not only in GATA3/SOX10-positive TNBCs but also in almost all GATA3/SOX10-negative TNBCs.
AbstractList	A diagnostic dilemma can be encountered when primary triple-negative breast carcinoma (TNBC) without an in situ component or metastatic TNBCs lose the currently used organ-specific marker such as GATA3, raising concerns about metastatic carcinoma from other sites. In the current study, we compared the newly identified breast marker TRPS1 with currently used breast markers GATA3 and SOX10 in whole-tissue sections from 315 cases of various subtypes of TNBC. TRPS1 was highly expressed in 100% of triple-negative primary and metastatic invasive lobular carcinomas, 99% of triple-negative primary and metastatic invasive breast carcinoma of no special type (IBC-NST), and 95% of metaplastic breast carcinomas. In contrast, GATA3 and SOX10 were expressed in 94% and 0% of invasive lobular carcinomas, 63% and 74% of IBC-NST, and 50% and 49% of metaplastic breast carcinomas, respectively. For special-type TNBCs, both TRPS1 and GATA3 were negative in acinic cell carcinomas, most cribriform adenoid cystic carcinomas, and neuroendocrine carcinomas, but positive in secretory carcinomas. Triple-negative apocrine carcinoma was the only subtype of TNBC with positive GATA3 but negative TRPS1. These data indicate that TRPS1 is a highly sensitive marker for TNBCs with positivity not only in GATA3/SOX10-positive TNBCs but also in almost all GATA3/SOX10-negative TNBCs.
Author	Peng, Yan Wu, Yun Ding, Qingqing Parkinson, Bryce Li, Zaibo Albarracin, Constance T. Yoon, Esther C. Huo, Lei Gan, Qiong Wang, Gang Parwani, Anil V. Salisbury, Taylor Wang, Jing Sun, Hongxia Chen, Wei Middleton, Lavinia P. Krishnamurthy, Savitri Shen, Tiansheng Sahin, Aysegul A. Chen, Hui Huang, Xiao Resetkova, Erika
Author_xml	– sequence: 1 givenname: Esther C. surname: Yoon fullname: Yoon, Esther C. organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 2 givenname: Gang surname: Wang fullname: Wang, Gang organization: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, V6T 2B5, Canada – sequence: 3 givenname: Bryce surname: Parkinson fullname: Parkinson, Bryce organization: Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA – sequence: 4 givenname: Lei surname: Huo fullname: Huo, Lei organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 5 givenname: Yan surname: Peng fullname: Peng, Yan organization: Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA – sequence: 6 givenname: Jing surname: Wang fullname: Wang, Jing organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 7 givenname: Taylor surname: Salisbury fullname: Salisbury, Taylor organization: Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, V6T 2B5, Canada – sequence: 8 givenname: Yun surname: Wu fullname: Wu, Yun organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 9 givenname: Hui surname: Chen fullname: Chen, Hui organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 10 givenname: Constance T. surname: Albarracin fullname: Albarracin, Constance T. organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 11 givenname: Erika surname: Resetkova fullname: Resetkova, Erika organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 12 givenname: Lavinia P. surname: Middleton fullname: Middleton, Lavinia P. organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 13 givenname: Savitri surname: Krishnamurthy fullname: Krishnamurthy, Savitri organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 14 givenname: Qiong surname: Gan fullname: Gan, Qiong organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 15 givenname: Hongxia surname: Sun fullname: Sun, Hongxia organization: Department of Pathology and Laboratory Medicine, The University of Texas McGovern Medical School, Houston, TX, 77030, USA – sequence: 16 givenname: Xiao surname: Huang fullname: Huang, Xiao organization: Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, 35294, USA – sequence: 17 givenname: Tiansheng surname: Shen fullname: Shen, Tiansheng organization: Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA – sequence: 18 givenname: Wei surname: Chen fullname: Chen, Wei organization: Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA – sequence: 19 givenname: Anil V. surname: Parwani fullname: Parwani, Anil V. organization: Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA – sequence: 20 givenname: Aysegul A. surname: Sahin fullname: Sahin, Aysegul A. email: asahin@mdanderson.org organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA – sequence: 21 givenname: Zaibo surname: Li fullname: Li, Zaibo email: zaibo.li@osumc.edu organization: Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA – sequence: 22 givenname: Qingqing surname: Ding fullname: Ding, Qingqing email: qqding@mdanderson.org organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
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Cites_doi	10.1016/j.prp.2019.152801 10.1093/annonc/mdt190 10.1200/JCO.19.02309 10.18632/oncotarget.16160 10.1038/ncb1530 10.1038/s41379-020-00692-8 10.1097/PAS.0b013e3181658c14 10.1097/PAS.0000000000001824 10.5858/arpa.2018-0902-SA 10.1097/PAS.0b013e3182a0218f 10.1097/PAI.0000000000000237 10.1097/PAI.0000000000000186 10.1136/jclinpath-2016-204137 10.1158/2159-8290.CD-18-1177 10.1016/j.anndiagpath.2014.12.001 10.1097/PAP.0b013e318297a9d0 10.1111/his.14118 10.1016/j.humpath.2020.06.004 10.1007/s10549-020-05818-9 10.1111/his.12645 10.1097/PAS.0000000000000398 10.1016/j.humpath.2012.09.005 10.1016/j.humpath.2012.11.003 10.1016/j.cell.2006.09.048 10.1101/gad.331371.119 10.1038/modpathol.2012.244 10.1097/PAI.0b013e318279bc0a
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Keywords	Invasive breast carcinoma of no special type Metaplastic carcinoma Triple-negative breast carcinoma TRPS1 GATA3 SOX10 Invasive lobular carcinoma
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References	Gazinska, Grigoriadis, Brown, Millis, Mera, Gillett (bib1) 2013; 26 Ordóñez (bib18) 2013; 20 Qazi, McGregor (bib21) 2020; 216 Cornelissen, Drenth, van der Burg, de Bruijn, Pritchard, Huijbers (bib16) 2020; 34 Garrido-Castro, Lin, Polyak (bib2) 2019; 9 Lin, Zeng, Liang, Wei, Chen (bib15) 2017; 8 Nonaka, Chiriboga, Rubin (bib20) 2008; 32 Tang, Yu, Xu, Cheng, Tu, Lu (bib11) 2017; 70 Allison, Hammond, Dowsett, McKernin, Carey, Fitzgibbons (bib26) 2020; 38 Yoon, Wilson, Zuo, Pinto, Cole, Harigopal (bib23) 2020; 102 Cimino-Mathews, Subhawong, Illei, Sharma, Halushka, Vang (bib8) 2013; 44 Huo, Gong, Guo, Gilcrease, Wu, Zhang (bib9) 2015; 67 Miettinen, McCue, Sarlomo-Rikala, Rys, Czapiewski, Wazny (bib7) 2014; 38 Kandalaft, Simon, Isacson, Gown (bib4) 2016; 24 Ai, Yao, Yang, Huo, Chen, Lu (bib12) 2021; 34 Miettinen, McCue, Sarlomo-Rikala, Biernat, Czapiewski, Kopczynski (bib19) 2015; 39 Jamidi, Hu, Aphivatanasiri, Tsang, Poon, Li (bib27) 2020; 77 Parkinson, Chen, Shen, Parwani, Li (bib13) 2022; 46 Chen, Bao, Lee, Murray, Litton, Xiao (bib14) 2013; 24 Cimino-Mathews, Subhawong, Elwood, Warzecha, Sharma, Park (bib22) 2013; 44 Sangoi, Shrestha, Yang, Mego, Beck (bib3) 2016; 24 Aphivatanasiri, Li, Chan, Jamidi, Tsang, Poon (bib24) 2020; 184 Asselin-Labat, Sutherland, Barker, Thomas, Shackleton, Forrest (bib6) 2007; 9 Mohamed, Gonzalez, Lawson, Wang, Cohen (bib17) 2013; 21 Wolff, Hammond, Allison, Harvey, Mangu, Bartlett (bib25) 2018; 142 Kouros-Mehr, Slorach, Sternlicht, Werb (bib5) 2006; 127 Wendroth, Mentrikoski, Wick (bib10) 2015; 19 Aphivatanasiri (10.1016/j.humpath.2022.04.006_bib24) 2020; 184 Wolff (10.1016/j.humpath.2022.04.006_bib25) 2018; 142 Miettinen (10.1016/j.humpath.2022.04.006_bib7) 2014; 38 Ordóñez (10.1016/j.humpath.2022.04.006_bib18) 2013; 20 Cornelissen (10.1016/j.humpath.2022.04.006_bib16) 2020; 34 Nonaka (10.1016/j.humpath.2022.04.006_bib20) 2008; 32 Parkinson (10.1016/j.humpath.2022.04.006_bib13) 2022; 46 Ai (10.1016/j.humpath.2022.04.006_bib12) 2021; 34 Garrido-Castro (10.1016/j.humpath.2022.04.006_bib2) 2019; 9 Yoon (10.1016/j.humpath.2022.04.006_bib23) 2020; 102 Lin (10.1016/j.humpath.2022.04.006_bib15) 2017; 8 Cimino-Mathews (10.1016/j.humpath.2022.04.006_bib22) 2013; 44 Chen (10.1016/j.humpath.2022.04.006_bib14) 2013; 24 Qazi (10.1016/j.humpath.2022.04.006_bib21) 2020; 216 Jamidi (10.1016/j.humpath.2022.04.006_bib27) 2020; 77 Gazinska (10.1016/j.humpath.2022.04.006_bib1) 2013; 26 Kandalaft (10.1016/j.humpath.2022.04.006_bib4) 2016; 24 Cimino-Mathews (10.1016/j.humpath.2022.04.006_bib8) 2013; 44 Asselin-Labat (10.1016/j.humpath.2022.04.006_bib6) 2007; 9 Miettinen (10.1016/j.humpath.2022.04.006_bib19) 2015; 39 Wendroth (10.1016/j.humpath.2022.04.006_bib10) 2015; 19 Allison (10.1016/j.humpath.2022.04.006_bib26) 2020; 38 Kouros-Mehr (10.1016/j.humpath.2022.04.006_bib5) 2006; 127 Tang (10.1016/j.humpath.2022.04.006_bib11) 2017; 70 Huo (10.1016/j.humpath.2022.04.006_bib9) 2015; 67 Mohamed (10.1016/j.humpath.2022.04.006_bib17) 2013; 21 Sangoi (10.1016/j.humpath.2022.04.006_bib3) 2016; 24
References_xml	– volume: 38 start-page: 13 year: 2014 end-page: 22 ident: bib7 article-title: GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors publication-title: Am J Surg Pathol contributor: fullname: Wazny – volume: 39 start-page: 826 year: 2015 end-page: 835 ident: bib19 article-title: Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors publication-title: Am J Surg Pathol contributor: fullname: Kopczynski – volume: 19 start-page: 16 year: 2015 end-page: 19 ident: bib10 article-title: GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin publication-title: Ann Diagn Pathol contributor: fullname: Wick – volume: 77 start-page: 936 year: 2020 end-page: 948 ident: bib27 article-title: Sry-related high-mobility-group/HMG box 10 (SOX10) as a sensitive marker for triple-negative breast cancer publication-title: Histopathology contributor: fullname: Li – volume: 21 start-page: 506 year: 2013 end-page: 510 ident: bib17 article-title: SOX10 expression in malignant melanoma, carcinoma, and normal tissues publication-title: Appl Immunohistochem Mol Morphol contributor: fullname: Cohen – volume: 34 start-page: 710 year: 2021 end-page: 719 ident: bib12 article-title: TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer publication-title: Mod Pathol contributor: fullname: Lu – volume: 24 start-page: 2534 year: 2013 end-page: 2542 ident: bib14 article-title: Prognostic value of the trichorhinophalangeal syndrome-1 (TRPS-1), a GATA family transcription factor, in early-stage breast cancer publication-title: Ann Oncol contributor: fullname: Xiao – volume: 216 start-page: 152801 year: 2020 ident: bib21 article-title: Combined use of SOX10 and GATA3 in mammary carcinoma publication-title: Pathol Res Pract contributor: fullname: McGregor – volume: 70 start-page: 926 year: 2017 end-page: 934 ident: bib11 article-title: Characterisation of GATA3 expression in invasive breast cancer: differences in histological subtypes and immunohistochemically defined molecular subtypes publication-title: J Clin Pathol contributor: fullname: Lu – volume: 102 start-page: 113 year: 2020 end-page: 122 ident: bib23 article-title: High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers publication-title: Hum Pathol contributor: fullname: Harigopal – volume: 24 start-page: 609 year: 2016 end-page: 614 ident: bib4 article-title: Comparative sensitivities and specificities of antibodies to breast markers GCDFP-15, mammaglobin A, and different clones of antibodies to GATA-3: a study of 338 tumors using whole sections publication-title: Appl Immunohistochem Mol Morphol contributor: fullname: Gown – volume: 44 start-page: 1341 year: 2013 end-page: 1349 ident: bib8 article-title: GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas publication-title: Hum Pathol contributor: fullname: Vang – volume: 44 start-page: 959 year: 2013 end-page: 965 ident: bib22 article-title: Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas publication-title: Hum Pathol contributor: fullname: Park – volume: 127 start-page: 1041 year: 2006 end-page: 1055 ident: bib5 article-title: GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland publication-title: Cell contributor: fullname: Werb – volume: 38 start-page: 1346 year: 2020 end-page: 1366 ident: bib26 article-title: Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update publication-title: J Clin Oncol contributor: fullname: Fitzgibbons – volume: 32 start-page: 1291 year: 2008 end-page: 1298 ident: bib20 article-title: Sox10: a pan-schwannian and melanocytic marker publication-title: Am J Surg Pathol contributor: fullname: Rubin – volume: 24 start-page: 229 year: 2016 end-page: 237 ident: bib3 article-title: The novel marker GATA3 is significantly more sensitive than traditional markers mammaglobin and GCDFP15 for identifying breast cancer in surgical and cytology specimens of metastatic and matched primary tumors publication-title: Appl Immunohistochem Mol Morphol contributor: fullname: Beck – volume: 9 start-page: 201 year: 2007 end-page: 209 ident: bib6 article-title: Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation publication-title: Nat Cell Biol contributor: fullname: Forrest – volume: 184 start-page: 111 year: 2020 end-page: 121 ident: bib24 article-title: Combined SOX10 GATA3 is most sensitive in detecting primary and metastatic breast cancers: a comparative study of breast markers in multiple tumors publication-title: Breast Cancer Res Treat contributor: fullname: Poon – volume: 9 start-page: 176 year: 2019 end-page: 198 ident: bib2 article-title: Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment publication-title: Cancer Discov contributor: fullname: Polyak – volume: 8 start-page: 34750 year: 2017 end-page: 34761 ident: bib15 article-title: GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancie publication-title: Oncotarget contributor: fullname: Chen – volume: 142 start-page: 1364 year: 2018 end-page: 1382 ident: bib25 article-title: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update publication-title: Arch Pathol Lab Med contributor: fullname: Bartlett – volume: 34 start-page: 179 year: 2020 end-page: 193 ident: bib16 article-title: TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development publication-title: Genes Dev contributor: fullname: Huijbers – volume: 46 start-page: 415 year: 2022 end-page: 423 ident: bib13 article-title: TRPS1 expression in breast carcinomas: focusing on metaplastic breast carcinomas publication-title: Am J Surg Pathol contributor: fullname: Li – volume: 26 start-page: 955 year: 2013 end-page: 966 ident: bib1 article-title: Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles publication-title: Mod Pathol contributor: fullname: Gillett – volume: 20 start-page: 275 year: 2013 end-page: 283 ident: bib18 article-title: Value of SOX10 immunostaining in tumor diagnosis publication-title: Adv Anat Pathol contributor: fullname: Ordóñez – volume: 67 start-page: 245 year: 2015 end-page: 254 ident: bib9 article-title: GATA-binding protein 3 enhances the utility of gross cystic disease fluid protein-15 and mammaglobin A in triple-negative breast cancer by immunohistochemistry publication-title: Histopathology contributor: fullname: Zhang – volume: 216 start-page: 152801 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib21 article-title: Combined use of SOX10 and GATA3 in mammary carcinoma publication-title: Pathol Res Pract doi: 10.1016/j.prp.2019.152801 contributor: fullname: Qazi – volume: 24 start-page: 2534 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib14 article-title: Prognostic value of the trichorhinophalangeal syndrome-1 (TRPS-1), a GATA family transcription factor, in early-stage breast cancer publication-title: Ann Oncol doi: 10.1093/annonc/mdt190 contributor: fullname: Chen – volume: 38 start-page: 1346 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib26 article-title: Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update publication-title: J Clin Oncol doi: 10.1200/JCO.19.02309 contributor: fullname: Allison – volume: 8 start-page: 34750 year: 2017 ident: 10.1016/j.humpath.2022.04.006_bib15 article-title: GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancie publication-title: Oncotarget doi: 10.18632/oncotarget.16160 contributor: fullname: Lin – volume: 9 start-page: 201 year: 2007 ident: 10.1016/j.humpath.2022.04.006_bib6 article-title: Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation publication-title: Nat Cell Biol doi: 10.1038/ncb1530 contributor: fullname: Asselin-Labat – volume: 34 start-page: 710 year: 2021 ident: 10.1016/j.humpath.2022.04.006_bib12 article-title: TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer publication-title: Mod Pathol doi: 10.1038/s41379-020-00692-8 contributor: fullname: Ai – volume: 32 start-page: 1291 year: 2008 ident: 10.1016/j.humpath.2022.04.006_bib20 article-title: Sox10: a pan-schwannian and melanocytic marker publication-title: Am J Surg Pathol doi: 10.1097/PAS.0b013e3181658c14 contributor: fullname: Nonaka – volume: 46 start-page: 415 year: 2022 ident: 10.1016/j.humpath.2022.04.006_bib13 article-title: TRPS1 expression in breast carcinomas: focusing on metaplastic breast carcinomas publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000001824 contributor: fullname: Parkinson – volume: 142 start-page: 1364 year: 2018 ident: 10.1016/j.humpath.2022.04.006_bib25 article-title: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update publication-title: Arch Pathol Lab Med doi: 10.5858/arpa.2018-0902-SA contributor: fullname: Wolff – volume: 38 start-page: 13 year: 2014 ident: 10.1016/j.humpath.2022.04.006_bib7 article-title: GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors publication-title: Am J Surg Pathol doi: 10.1097/PAS.0b013e3182a0218f contributor: fullname: Miettinen – volume: 24 start-page: 609 year: 2016 ident: 10.1016/j.humpath.2022.04.006_bib4 article-title: Comparative sensitivities and specificities of antibodies to breast markers GCDFP-15, mammaglobin A, and different clones of antibodies to GATA-3: a study of 338 tumors using whole sections publication-title: Appl Immunohistochem Mol Morphol doi: 10.1097/PAI.0000000000000237 contributor: fullname: Kandalaft – volume: 24 start-page: 229 year: 2016 ident: 10.1016/j.humpath.2022.04.006_bib3 article-title: The novel marker GATA3 is significantly more sensitive than traditional markers mammaglobin and GCDFP15 for identifying breast cancer in surgical and cytology specimens of metastatic and matched primary tumors publication-title: Appl Immunohistochem Mol Morphol doi: 10.1097/PAI.0000000000000186 contributor: fullname: Sangoi – volume: 70 start-page: 926 year: 2017 ident: 10.1016/j.humpath.2022.04.006_bib11 article-title: Characterisation of GATA3 expression in invasive breast cancer: differences in histological subtypes and immunohistochemically defined molecular subtypes publication-title: J Clin Pathol doi: 10.1136/jclinpath-2016-204137 contributor: fullname: Tang – volume: 9 start-page: 176 year: 2019 ident: 10.1016/j.humpath.2022.04.006_bib2 article-title: Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-18-1177 contributor: fullname: Garrido-Castro – volume: 19 start-page: 16 year: 2015 ident: 10.1016/j.humpath.2022.04.006_bib10 article-title: GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin publication-title: Ann Diagn Pathol doi: 10.1016/j.anndiagpath.2014.12.001 contributor: fullname: Wendroth – volume: 20 start-page: 275 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib18 article-title: Value of SOX10 immunostaining in tumor diagnosis publication-title: Adv Anat Pathol doi: 10.1097/PAP.0b013e318297a9d0 contributor: fullname: Ordóñez – volume: 77 start-page: 936 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib27 article-title: Sry-related high-mobility-group/HMG box 10 (SOX10) as a sensitive marker for triple-negative breast cancer publication-title: Histopathology doi: 10.1111/his.14118 contributor: fullname: Jamidi – volume: 102 start-page: 113 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib23 article-title: High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers publication-title: Hum Pathol doi: 10.1016/j.humpath.2020.06.004 contributor: fullname: Yoon – volume: 184 start-page: 111 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib24 article-title: Combined SOX10 GATA3 is most sensitive in detecting primary and metastatic breast cancers: a comparative study of breast markers in multiple tumors publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-020-05818-9 contributor: fullname: Aphivatanasiri – volume: 67 start-page: 245 year: 2015 ident: 10.1016/j.humpath.2022.04.006_bib9 article-title: GATA-binding protein 3 enhances the utility of gross cystic disease fluid protein-15 and mammaglobin A in triple-negative breast cancer by immunohistochemistry publication-title: Histopathology doi: 10.1111/his.12645 contributor: fullname: Huo – volume: 39 start-page: 826 year: 2015 ident: 10.1016/j.humpath.2022.04.006_bib19 article-title: Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors publication-title: Am J Surg Pathol doi: 10.1097/PAS.0000000000000398 contributor: fullname: Miettinen – volume: 44 start-page: 959 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib22 article-title: Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas publication-title: Hum Pathol doi: 10.1016/j.humpath.2012.09.005 contributor: fullname: Cimino-Mathews – volume: 44 start-page: 1341 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib8 article-title: GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas publication-title: Hum Pathol doi: 10.1016/j.humpath.2012.11.003 contributor: fullname: Cimino-Mathews – volume: 127 start-page: 1041 year: 2006 ident: 10.1016/j.humpath.2022.04.006_bib5 article-title: GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland publication-title: Cell doi: 10.1016/j.cell.2006.09.048 contributor: fullname: Kouros-Mehr – volume: 34 start-page: 179 year: 2020 ident: 10.1016/j.humpath.2022.04.006_bib16 article-title: TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development publication-title: Genes Dev doi: 10.1101/gad.331371.119 contributor: fullname: Cornelissen – volume: 26 start-page: 955 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib1 article-title: Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles publication-title: Mod Pathol doi: 10.1038/modpathol.2012.244 contributor: fullname: Gazinska – volume: 21 start-page: 506 year: 2013 ident: 10.1016/j.humpath.2022.04.006_bib17 article-title: SOX10 expression in malignant melanoma, carcinoma, and normal tissues publication-title: Appl Immunohistochem Mol Morphol doi: 10.1097/PAI.0b013e318279bc0a contributor: fullname: Mohamed
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Snippet	A diagnostic dilemma can be encountered when primary triple-negative breast carcinoma (TNBC) without an in situ component or metastatic TNBCs lose the...
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SubjectTerms	Breast cancer GATA3 Invasive breast carcinoma of no special type Invasive lobular carcinoma Melanoma Metaplastic carcinoma Metastasis Monoclonal antibodies SOX10 Stains & staining Triple-negative breast carcinoma TRPS1 Tumors
Title	TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma
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