Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance

• Published in: Anais da Academia Brasileira de Ciências Vol. 91; no. 4
• Main Authors: HERRERA, KARINA M.S., FERREIRA, LORENA S., BRAGA, ALYSSON V., SOUZA, JULIANO P., ANDRADE, JÉSSICA T., SOARES, ADRIANA C., SOARES, LUIS F., CHAGAS, RAFAEL C.R., FERREIRA, JAQUELINE M.S.
• Format: Journal Article
• Language: English
• Published: Academia Brasileira de Ciências 01-01-2019
• Subjects: 1,2-bis-bis (2-thiazolin-2-isulfanyl) ethane; antimicrobial activity; complexes; hidrotris (2-mercaptothiazolyl) borate; MULTIDISCIPLINARY SCIENCES; 1,2-bis-bis (2-thiazolin-2-isulfanyl) ethane; hidrotris (2-mercaptothiazolyl) borate; antimicrobial activity; complexes
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/0001-376520181077

Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism.