The do-not-resuscitate-like (DNRL) order, a medical directive for limiting life-sustaining treatment in the end-of-life care of children with cancer: experience of major cancer center in Brazil

• Published in: Supportive care in cancer Vol. 30; no. 5; pp. 4283 - 4289
• Main Authors: de Wylson Fernandes Gomes de Mattos, Debora, Thuler, Luiz Claudio, da Silva Lima, Fernanda Ferreira, de Camargo, Beatriz, Ferman, Sima
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2022; Springer; Springer Nature B.V
• Subjects: Analysis; Brazil; Cancer; Child; Children; Development and progression; Do-not-resuscitate orders; Health aspects; Humans; Medical records; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Neoplasms - therapy; Nursing; Nursing Research; Oncology; Original Article; Pain Medicine; Palliative Care; Palliative treatment; Pediatrics; Rehabilitation Medicine; Resuscitation Orders; Retrospective Studies; Terminal Care; Tumors; Brazil; Solid tumor; Do-not-resuscitate order; Pediatric; Palliative care medicine; Cancer
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-021-06717-5

Purpose
In the last few decades, interest in palliative care and advance care planning has grown in Brazil and worldwide. Empirical studies are needed to reduce therapeutic obstinacy and medical futility in the end-of-life care of children with incurable cancer. The aim of this study was to investigate the effects of do-not-resuscitate-like (DNRL) orders on the quality of end-of-life care of children with incurable solid tumors at a cancer center in Brazil.
Methods
A retrospective observational cohort study of 181 pediatric patients with solid tumors followed at the Pediatric Oncology Department of the Brazilian National Cancer Institute, Rio de Janeiro, Brazil, who died due to disease progression from 2009 to 2013. Medical records were reviewed for indicators of quality of end-of-life care, including overtreatment, care planning, and care at death, in addition to documentation of the diagnosis of life-limiting illness and the presence of a DNRL order. Data were summarized using descriptive statistics. Univariate and multivariate logistic regression analyses were used to examine associations between demographics, disease, treatment, and indicators of end-of-life care with a DNRL order.
Results
A documented DNRL order was associated with lower odds of dying in the intensive care unit or emergency room (80%), dying within 30 days of endotracheal tube placement (80%), or cardiopulmonary resuscitation (CPR) administration at the time of death (96%).
Conclusion
Placement of DNRL orders early in the disease process is critical in reducing futile treatment in pediatric patients with incurable cancer.