Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility

Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, , is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sarcomagenesis have proven unsuc...

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Bibliographic Details

Published in:	Cancers Vol. 12; no. 4; p. 948
Main Authors:	Miller, Henry E, Gorthi, Aparna, Bassani, Nicklas, Lawrence, Liesl A, Iskra, Brian S, Bishop, Alexander J R
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 11-04-2020
Subjects:	developmental trajectories Ewing sarcoma replication stress cell identity transcriptomics R-loops single cell biology EWSR1-FLI1 sarcomagenesis manifold learning
Online Access:	Get full text
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