Embryonic overexpression of receptors for advanced glycation end-products by alveolar epithelium induces an imbalance between proliferation and apoptosis

Receptors for advanced glycation end-products (RAGEs) are multiligand cell surface receptors highly expressed in the lung that contribute to alveolar epithelial cell differentiation during embryogenesis and the modulation of pulmonary inflammation during disease. When RAGEs are overexpressed through...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 47; no. 1; pp. 60 - 66
Main Authors:	Stogsdill, Jeffrey A, Stogsdill, Megan P, Porter, Jason L, Hancock, Joshua M, Robinson, Adam B, Reynolds, Paul R
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01-07-2012
Subjects:	Alveolar Epithelial Cells - cytology Alveolar Epithelial Cells - metabolism Animals Apoptosis Cell Nucleus - metabolism Cell Proliferation Fas Ligand Protein - biosynthesis Lung - abnormalities Lung - cytology Lung - embryology Lung - metabolism Mice Mice, Inbred C57BL Mice, Transgenic NF-kappa B - metabolism Organogenesis Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Signal Transduction
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