In vivo activity of (8-hydroxymethylen)-trieicosanyl acetate against Trypanosoma cruzi during acute phase of the infection

• Published in: African journal of traditional, complementary, and alternative medicines Vol. 8; no. 5 Suppl; pp. 198 - 207
• Main Authors: Jiménez-Coello, Matilde, Acosta-Viana, Karla Yolanda, Pérez G, Maria Salud, Guzmán-Marín, Eugenia del S
• Format: Journal Article
• Language: English
• Published: Nigeria African Networks on Ethnomedicines 01-01-2011
• Subjects: Acetates - isolation & purification; Acetates - pharmacology; Acetates - therapeutic use; Administration, Oral; Animals; Chagas Disease - drug therapy; Chagas Disease - parasitology; Dose-Response Relationship, Drug; Eicosanoids - isolation & purification; Eicosanoids - pharmacology; Eicosanoids - therapeutic use; Fabaceae - chemistry; Heart - parasitology; Mice; Mice, Inbred BALB C; Parasitemia - drug therapy; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Research Papers; Trypanocidal Agents - isolation & purification; Trypanocidal Agents - pharmacology; Trypanocidal Agents - therapeutic use; Trypanosoma cruzi - drug effects; Senna villosa; antiprotozoal; in vivo; Chagas' disease
• ISSN: 0189-6016; 2505-0044; 0189-6016
• DOI: 10.4314/ajtcam.v8i5S.26

The antiprotozoal activity in vivo against Trypanosoma cruzi of (8-hydroxymethylen)-trieicosanyl acetate was evaluated in BALB/c mice during the acute phase of Chagas' disease (15 days after infection). Animals were treated during 15 days at doses of 16.8 and 33.6 µg/g, reduced parasitemia of 77.6 and 64.1% was observed respectively, in comparison with positive control mice (allopurinol 8.5 µg/g) which reduced only 29.7%. Also, amastigote nests in cardiac tissue were significant reduced in treated mice groups. The regression of effect induced after the suppression of the treatment with the compound was evaluated; animals were infected and simultaneously began the treatment with the compound during 20 days (16.8 and 33.6 µg/g). Mice were monitored after the end of the treatment for one more week. A good antitrypanosomal response was observed (66.1 and 68.9% less than untreated mice) during treatment, but 8 days after suspension of treatment, parasitemia level increased, reducing only 58.6 and 56.29 % respectively in treated animals compared with no treated.