Chest pain in asbestos and silica-exposed workers

• Published in: Occupational medicine (Oxford) Vol. 61; no. 3; pp. 178 - 183
• Main Authors: PARK, E.-K, THOMAS, P. S, WILSON, D, CHOI, H. J, JOHNSON, A. R, YATES, D. H
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-05-2011
• Subjects: Aged; Asbestos; Asbestos - toxicity; Australia - epidemiology; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; Chest Pain - epidemiology; Chest Pain - etiology; Dust; Epidemiologic Methods; Female; Humans; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.); Lung Diseases - complications; Male; Medical sciences; Middle Aged; Occupational Diseases - epidemiology; Occupational Diseases - etiology; Occupational Exposure - adverse effects; Pleural Diseases - complications; Silicon Dioxide - toxicity; Surveys and Questionnaires; Toxicology; Australia; Oceania; Human; Asbestos; Prevalence; Disease; Occupational exposure; Respiratory system; Silica; Inorganic compound; Symptomatology; respiratory symptoms; Worker; Thoracic pain; asbestos-related diseases; Occupational medicine
• ISSN: 0962-7480; 1471-8405
• DOI: 10.1093/occmed/kqr011

Chest pain may be the first symptom of developing respiratory malignancy, particularly in subjects with asbestos exposure, yet little information exists on this topic.
To investigate chest pain in a cohort of subjects exposed to asbestos and silica dust applying for compensation.
Cross-sectional study using a standardized questionnaire. Data collection included: smoking history, Medical Research Council scales of exercise capacity and respiratory symptoms.
We studied 621 subjects. Six disease groups were categorized: asbestosis (n = 27), diffuse pleural thickening (DPT) (132), asbestosis and DPT (14), silicosis (26), pleural plaques only (160) and healthy subjects with a history of dust exposure (256). Crude prevalence rates of chest pain were high, with chest pain approximately twice as common in subjects with asbestos-related disorders and silicosis as in healthy subjects, with an overall frequency of ~40%. However, when other variables were taken into account in a multivariate analysis the differences between groups disappeared. The factor most significantly related to chest pain was age.
Chest pain is apparently common in subjects with asbestos-related disorders and silicosis, but after adjustment for other variables, no increased prevalence was apparent in subjects with pleural disorders. More sophisticated questionnaires and dedicated imaging are required to elucidate this further.