Chiral Bis(N-sulfonylamino)phosphine- and TADDOL-Phosphite-Oxazoline Ligands: Synthesis and Application in Asymmetric Catalysis

• Published in: Advanced synthesis & catalysis Vol. 347; no. 1; pp. 61 - 77
• Main Authors: Hilgraf, Robert, Pfaltz, Andreas
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01-01-2005; WILEY‐VCH Verlag
• Subjects: asymmetric allylic substitution; asymmetric catalysis; asymmetric hydrogenation; N,P ligands; oxazolines; P ligands
• ISSN: 1615-4150; 1615-4169
• DOI: 10.1002/adsc.200404168

A series of N,P‐ligands has been prepared, containing a chiral oxazoline ring and as a second chiral unit a bis(N‐sulfonylamino)phosphine group embedded in a diazaphospholidine ring or a cyclic phosphite group derived from TADDOL. These modular ligands are readily synthesized from chiral amino alcohols and chiral 1,2‐diamines or TADDOLs. Palladium and iridium complexes derived from these ligands were found to be efficient catalysts for enantioselective allylic alkylation and olefin hydrogenation, respectively.