A Novel β-Hairpin Peptide Z-d14CFR Enhances Multidrug-Resistant Bacterial Clearance in a Murine Model of Mastitis

The widespread prevalence of antimicrobial resistance has spawned the development of novel antimicrobial agents. Antimicrobial peptides (AMPs) have gained comprehensive attention as one of the major alternatives to antibiotics. However, low antibacterial activity and high-cost production have limite...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 9; p. 4617
Main Authors:	Wang, Xue, Li, Shuxian, Du, Mengze, Liu, Ning, Shan, Qiang, Zou, Yunjing, Wang, Jiufeng, Zhu, Yaohong
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21-04-2022 MDPI
Subjects:	Animal models Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Infective Agents - pharmacology Antibacterial activity Antibiotics Antimicrobial activity Antimicrobial agents antimicrobial peptide Antimicrobial Peptides Antimicrobial resistance Bacteria Bacterial infections Biofilms Chemical bonds Clearances Cytotoxicity defensin Defensins - pharmacology Disease Models, Animal Drug resistance E coli Escherichia coli Female Gram-negative bacteria Gram-positive bacteria Humans IL-1β Interleukin 1 Leukocytes (neutrophilic) Mass spectrometry Mastitis Mastitis - drug therapy Metastases Mice Microbial Sensitivity Tests Multidrug resistance Multidrug resistant organisms multidrug-resistant bacteria Pathogens Peptides Peptides - pharmacology Scientific imaging Tumor necrosis factor-α Zophobas atratus β-hairpin multidrug-resistant bacteria Zophobas atratus β-hairpin mastitis antimicrobial peptide defensin
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