Asymmetric Total Synthesis of Stagonolide G

A simple asymmetric total synthesis of stagonolide G (1) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐catalyzed ring‐closing metathesis (RCM).

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Bibliographic Details
Published in:	Helvetica chimica acta Vol. 94; no. 7; pp. 1226 - 1233
Main Authors:	Ramesh, Dasari, Rajaram, Singanaboina, Prabhakar, Peddikotla, Ramulu, Udugu, Kumar Reddy, Dorigondla, Venkateswarlu, Yenamandra
Format:	Journal Article
Language:	English
Published:	Zürich WILEY-VCH Verlag 01-07-2011 WILEY‐VCH Verlag
Subjects:	Dihydroxylation Epoxide opening Grignard reaction Ring-closing methathesis Stagonolide G
Online Access:	Get full text
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Description
Summary:	A simple asymmetric total synthesis of stagonolide G (1) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐catalyzed ring‐closing metathesis (RCM).
Bibliography:	ark:/67375/WNG-LP7VQXDR-R ArticleID:HLCA201000416 istex:EFD491A6FACD57CC602965912A8769425EDF0115
ISSN:	0018-019X 1522-2675
DOI:	10.1002/hlca.201000416