Evaluation of the Effects of Apatinib on the Pharmacokinetics of Venlafaxine and O‐desmethylvenlafaxine in SD Male Rats by UPLC–MS/MS

The objective of this study was to evaluate the effect of apatinib on the pharmacokinetics of venlafaxine and O‐desmethylvenlafaxine in SD rats and the inhibitory effects of apatinib on venlafaxine in rat and human liver microsomes. Twenty‐one SD male rats were randomly divided into three groups (n...

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Bibliographic Details
Published in:	Basic & clinical pharmacology & toxicology Vol. 123; no. 6; pp. 721 - 726
Main Authors:	Bao, Su‐su, Wen, Jian, Lin, Qian‐meng, Li, Ying‐hui, Huang, Yang‐ge, Zhou, Hong‐yu, Hu, Guo‐xin
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-12-2018
Subjects:	Animals Chromatography, High Pressure Liquid Desvenlafaxine Succinate - blood Desvenlafaxine Succinate - pharmacokinetics Drug Interactions Humans Inhibitory Concentration 50 Liver Male Mass Spectrometry Microsomes Microsomes, Liver - drug effects Pharmacokinetics Pharmacology Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Rodents Venlafaxine Venlafaxine Hydrochloride - blood Venlafaxine Hydrochloride - pharmacokinetics
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