A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples

A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluori...

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Published in:	Analytical biochemistry Vol. 596; p. 113636
Main Authors:	Yoon, Alexander J., Wu, Haiqiang, Pan, Roy D., Teter, Bruce, Cipolla, Jack, Chang, Edwin, Avila, Luis Z., Basak, Saroj K., Srivatsan, Eri S., Wang, Marilene B., Cole, Greg M., Frautschy, Sally A., Hampton, Phillip D., Faull, Kym F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-05-2020
Subjects:	Animals Boranes - chemistry Boron trifluoride (BF3) Chromatography, Liquid Curcumin Curcuminoids Diarylheptanoids - blood Diarylheptanoids - chemistry Diarylheptanoids - isolation & purification Healthy Volunteers Humans Liquid chromatography coupled mass spectrometry (LCMS) Mass Spectrometry Mice Molecular Structure Pharmacokinetics Curcumin Liquid chromatography coupled mass spectrometry (LCMS) Boron trifluoride (BF3) Pharmacokinetics Curcuminoids Boron trifluoride (BF)
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Abstract	A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSn scan mode. The method has superb limits of detection of 0.01 nM for all curcuminoids and 0.5 nM for TC and the glucuroniated metabolites, and several representative chromatograms of biological samples containing these analytes are provided. In addition, the pharmacokinetic profile of these compounds in one human who daily consumed an over-the-counter curcuminoid product shows the peak and changes in circulating concentrations achieved by this mode of administration. [Display omitted] •Conversion of curcuminoids into BF2-curcuminoid complexes can be achieved in a simple one-step reaction, optimized for LC-MS analysis.•BF2-curcuminoid complexes yield an average of 28 fold increase in sensitivity on the negative ESI analysis.•The improved sensitivity of the assay enabled quantitation of these compounds in small amounts of soft tissues.•We demonstrate the application of our assay by analyzing human plasma and various soft tissues from mice.
AbstractList	A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MSn scan mode. The method has superb limits of detection of 0.01 nM for all curcuminoids and 0.5 nM for TC and the glucuroniated metabolites, and several representative chromatograms of biological samples containing these analytes are provided. In addition, the pharmacokinetic profile of these compounds in one human who daily consumed an over-the-counter curcuminoid product shows the peak and changes in circulating concentrations achieved by this mode of administration. [Display omitted] •Conversion of curcuminoids into BF2-curcuminoid complexes can be achieved in a simple one-step reaction, optimized for LC-MS analysis.•BF2-curcuminoid complexes yield an average of 28 fold increase in sensitivity on the negative ESI analysis.•The improved sensitivity of the assay enabled quantitation of these compounds in small amounts of soft tissues.•We demonstrate the application of our assay by analyzing human plasma and various soft tissues from mice. A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MS scan mode. The method has superb limits of detection of 0.01 nM for all curcuminoids and 0.5 nM for TC and the glucuroniated metabolites, and several representative chromatograms of biological samples containing these analytes are provided. In addition, the pharmacokinetic profile of these compounds in one human who daily consumed an over-the-counter curcuminoid product shows the peak and changes in circulating concentrations achieved by this mode of administration.
ArticleNumber	113636
Author	Hampton, Phillip D. Faull, Kym F. Avila, Luis Z. Basak, Saroj K. Cole, Greg M. Cipolla, Jack Pan, Roy D. Chang, Edwin Teter, Bruce Yoon, Alexander J. Srivatsan, Eri S. Frautschy, Sally A. Wang, Marilene B. Wu, Haiqiang
Author_xml	– sequence: 1 givenname: Alexander J. surname: Yoon fullname: Yoon, Alexander J. email: yoon2887@g.ucla.edu organization: Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA – sequence: 2 givenname: Haiqiang surname: Wu fullname: Wu, Haiqiang organization: Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA – sequence: 3 givenname: Roy D. surname: Pan fullname: Pan, Roy D. organization: Department of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA – sequence: 4 givenname: Bruce surname: Teter fullname: Teter, Bruce organization: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA – sequence: 5 givenname: Jack surname: Cipolla fullname: Cipolla, Jack organization: Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA – sequence: 6 givenname: Edwin surname: Chang fullname: Chang, Edwin organization: Department of Radiology, Stanford University, Stanford, CA 94305, USA – sequence: 7 givenname: Luis Z. surname: Avila fullname: Avila, Luis Z. organization: Aveta Biomics, Bedford, MA, 01730, USA – sequence: 8 givenname: Saroj K. surname: Basak fullname: Basak, Saroj K. organization: Department of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA – sequence: 9 givenname: Eri S. surname: Srivatsan fullname: Srivatsan, Eri S. organization: Department of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA – sequence: 10 givenname: Marilene B. surname: Wang fullname: Wang, Marilene B. organization: Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA – sequence: 11 givenname: Greg M. surname: Cole fullname: Cole, Greg M. organization: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA – sequence: 12 givenname: Sally A. surname: Frautschy fullname: Frautschy, Sally A. organization: Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA – sequence: 13 givenname: Phillip D. surname: Hampton fullname: Hampton, Phillip D. organization: Department of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA – sequence: 14 givenname: Kym F. surname: Faull fullname: Faull, Kym F. organization: Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
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Cites_doi	10.1016/j.jchromb.2013.12.039 10.4103/2231-4040.137448 10.1016/j.lfs.2005.12.007 10.1016/j.neulet.2008.09.067 10.1016/j.jpba.2018.04.034 10.3762/bjoc.13.223 10.1016/j.jtcme.2016.05.005 10.1186/2008-2231-21-11 10.5740/jaoacint.18-0269 10.1016/S0304-3835(98)00092-5 10.1248/cpb.41.1640 10.1002/dta.1472 10.1002/bmc.1584 10.1016/0378-5173(89)90253-6 10.1016/j.cell.2007.08.024 10.1002/bmc.1244 10.1016/j.brainres.2011.05.022 10.1093/carcin/bgm123
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Keywords	Curcumin Liquid chromatography coupled mass spectrometry (LCMS) Boron trifluoride (BF3) Pharmacokinetics Curcuminoids Boron trifluoride (BF)
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References	Ahmad, Warsi, Iqbal, Samim, Ahmad (bib17) 2014; 6 Tønnesen (bib9) 1989; 51 Singh (bib1) 2007; 130 Mishra, Dewangan, Singh, Hazra, Mandal (bib13) 2014; 5 Bae, Kim, Jeong, Lee, Kim, Kim, Yun, Bae, Kim (bib2) 2006; 15 Simon, Allais, Duroux, Basly, Durand-Fontanier, Delage (bib6) 1998; 129 bib11 Maheshwari, Singh, Gaddipati, Srimal (bib3) 2006; 78 Zhang, Wu, Meng, Yuan, Cai, Wang, Yang (bib5) 2008; 447 Sandur, Pandey, Sung, Ahn, Murakami, Sethi, Limtrakul, Badmaev, Aggarwal (bib8) 2007; 28 Kiuchi, Goto, Sugimoto, Akao, Kondo, Tsuda (bib10) 1993; 41 Han, Zhu, Wang, Wang, Liao (bib14) 2011; 25 Li, Jiang, Wen, Fan, Wu, Zhang (bib15) 2009; 23 Weiss, Reichel, Görls, Schneider, Micheel, Pröhl, Gottschaldt, Dietzek, Weigand (bib20) 2017; 13 Cao, Xu, Liu (bib19) 2014; 949–950 Kunati, Yang, William, Xu (bib16) 2018; 156 Verma, Najar, Tikoo, Singh, Gupta, Anand, Khajuria, Sharma, Johri (bib18) 2013; 21 Nasr, Abdel Rahman (bib12) 2019; 102 Ahmed, Gilani (bib7) 2011; 1400 Basak, Bera, Yoon, Morselli, Jeong, Tosevska, Dong, Eklund, Russ, Nasser, Lagishetty, Guo, Sajed, Mudgal, Mehta, Avila, Srivastava, Faull, Jacobs, Pellegrini, Shin, Srivatsan, Wang (bib21) 2020 Amalraj, Pius, Gopi, Gopi (bib4) 2016; 7 Singh (10.1016/j.ab.2020.113636_bib1) 2007; 130 Basak (10.1016/j.ab.2020.113636_bib21) 2020 Amalraj (10.1016/j.ab.2020.113636_bib4) 2016; 7 Kunati (10.1016/j.ab.2020.113636_bib16) 2018; 156 Li (10.1016/j.ab.2020.113636_bib15) 2009; 23 Weiss (10.1016/j.ab.2020.113636_bib20) 2017; 13 Verma (10.1016/j.ab.2020.113636_bib18) 2013; 21 Zhang (10.1016/j.ab.2020.113636_bib5) 2008; 447 Bae (10.1016/j.ab.2020.113636_bib2) 2006; 15 Sandur (10.1016/j.ab.2020.113636_bib8) 2007; 28 Kiuchi (10.1016/j.ab.2020.113636_bib10) 1993; 41 Ahmed (10.1016/j.ab.2020.113636_bib7) 2011; 1400 Nasr (10.1016/j.ab.2020.113636_bib12) 2019; 102 Maheshwari (10.1016/j.ab.2020.113636_bib3) 2006; 78 Tønnesen (10.1016/j.ab.2020.113636_bib9) 1989; 51 Cao (10.1016/j.ab.2020.113636_bib19) 2014; 949–950 Han (10.1016/j.ab.2020.113636_bib14) 2011; 25 Ahmad (10.1016/j.ab.2020.113636_bib17) 2014; 6 Simon (10.1016/j.ab.2020.113636_bib6) 1998; 129 Mishra (10.1016/j.ab.2020.113636_bib13) 2014; 5
References_xml	– volume: 130 start-page: 765 year: 2007 end-page: 768 ident: bib1 article-title: From exotic spice to modern drug? publication-title: Cell contributor: fullname: Singh – volume: 6 start-page: 257 year: 2014 end-page: 267 ident: bib17 article-title: Quantification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin in rodent brain by UHPLC/ESI-Q-TOF-MS/MS after intra-nasal administration of curcuminoids loaded PNIPAM nanoparticles publication-title: Drug Test. Anal. contributor: fullname: Ahmad – volume: 25 start-page: 1144 year: 2011 end-page: 1149 ident: bib14 article-title: A simple RP-HPLC method for the simultaneous determination of curcumin and its prodrug, curcumin didecanoate, in rat plasma and the application to pharmacokinetic study publication-title: Biomed. Chromatogr. contributor: fullname: Liao – volume: 7 start-page: 205 year: 2016 end-page: 233 ident: bib4 article-title: Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review publication-title: J. Tradit. Complement. Med. contributor: fullname: Gopi – volume: 156 start-page: 189 year: 2018 end-page: 198 ident: bib16 article-title: An LC–MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial publication-title: J. Pharmaceut. Biomed. Anal. contributor: fullname: Xu – volume: 1400 start-page: 1 year: 2011 end-page: 18 ident: bib7 article-title: A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease publication-title: Brain Res. contributor: fullname: Gilani – volume: 129 start-page: 111 year: 1998 end-page: 116 ident: bib6 article-title: Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure–activity relationships publication-title: Canc. Lett. contributor: fullname: Delage – ident: bib11 – volume: 51 start-page: 179 year: 1989 end-page: 181 ident: bib9 article-title: Studies on curcumin and curcuminoids. XV. Catalytic effect of demethoxy- and bisdemethoxycurcumin on the peroxidation of linoleic acid by 15-lipoxygenase publication-title: Int. J. Pharm. contributor: fullname: Tønnesen – volume: 5 start-page: 147 year: 2014 ident: bib13 article-title: A simple reversed phase high-performance liquid chromatography (RP-HPLC) method for determination of curcumin in aqueous humor of rabbit publication-title: J. Adv. Pharm. Technol. Research contributor: fullname: Mandal – volume: 78 start-page: 2081 year: 2006 end-page: 2087 ident: bib3 article-title: Multiple biological activities of curcumin: a short review publication-title: Life Sci. contributor: fullname: Srimal – volume: 15 start-page: 1557 year: 2006 end-page: 1562 ident: bib2 article-title: Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1 publication-title: Oncol. Rep. contributor: fullname: Kim – volume: 23 start-page: 1201 year: 2009 end-page: 1207 ident: bib15 article-title: A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome publication-title: Biomed. Chromatogr. contributor: fullname: Zhang – volume: 102 start-page: 1095 year: 2019 end-page: 1101 ident: bib12 article-title: Simultaneous determination of curcumin and resveratrol in lipidic nanoemulsion formulation and rat plasma using HPLC: optimization and application to real samples publication-title: J. AOAC Int. contributor: fullname: Abdel Rahman – volume: 28 start-page: 1765 year: 2007 end-page: 1773 ident: bib8 article-title: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism publication-title: Carcinogenesis contributor: fullname: Aggarwal – volume: 949–950 start-page: 70 year: 2014 end-page: 78 ident: bib19 article-title: A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry publication-title: J. Chromatogr. B contributor: fullname: Liu – volume: 447 start-page: 48 year: 2008 end-page: 53 ident: bib5 article-title: Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide publication-title: Neurosci. Lett. contributor: fullname: Yang – volume: 13 start-page: 2264 year: 2017 end-page: 2272 ident: bib20 article-title: Curcuminoid–BF2 complexes: synthesis, fluorescence and optimization of BF2 group cleavage publication-title: Beilstein J. Org. Chem. contributor: fullname: Weigand – volume: 21 start-page: 11 year: 2013 ident: bib18 article-title: Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice publication-title: DARU J. Pharm. Sci. contributor: fullname: Johri – volume: 41 start-page: 1640 year: 1993 end-page: 1643 ident: bib10 article-title: Nematocidal activity of Turmeric : synergistic action of curcuminoids publication-title: Chem. Pharm. Bull. (Tokyo) contributor: fullname: Tsuda – year: 2020 ident: bib21 article-title: A Randomized Phase-I Placebo-Controlled Trial of APG-157 in Oral Cancer Shows Systemic Absorption and an Inhibitory Effect on Cytokines and Tumor-Associated Microbes contributor: fullname: Wang – volume: 949–950 start-page: 70 year: 2014 ident: 10.1016/j.ab.2020.113636_bib19 article-title: A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry publication-title: J. Chromatogr. B doi: 10.1016/j.jchromb.2013.12.039 contributor: fullname: Cao – volume: 5 start-page: 147 year: 2014 ident: 10.1016/j.ab.2020.113636_bib13 article-title: A simple reversed phase high-performance liquid chromatography (RP-HPLC) method for determination of curcumin in aqueous humor of rabbit publication-title: J. Adv. Pharm. Technol. Research doi: 10.4103/2231-4040.137448 contributor: fullname: Mishra – volume: 78 start-page: 2081 year: 2006 ident: 10.1016/j.ab.2020.113636_bib3 article-title: Multiple biological activities of curcumin: a short review publication-title: Life Sci. doi: 10.1016/j.lfs.2005.12.007 contributor: fullname: Maheshwari – year: 2020 ident: 10.1016/j.ab.2020.113636_bib21 contributor: fullname: Basak – volume: 447 start-page: 48 year: 2008 ident: 10.1016/j.ab.2020.113636_bib5 article-title: Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2008.09.067 contributor: fullname: Zhang – volume: 15 start-page: 1557 year: 2006 ident: 10.1016/j.ab.2020.113636_bib2 article-title: Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1 publication-title: Oncol. Rep. contributor: fullname: Bae – volume: 156 start-page: 189 year: 2018 ident: 10.1016/j.ab.2020.113636_bib16 article-title: An LC–MS/MS method for simultaneous determination of curcumin, curcumin glucuronide and curcumin sulfate in a phase II clinical trial publication-title: J. Pharmaceut. Biomed. Anal. doi: 10.1016/j.jpba.2018.04.034 contributor: fullname: Kunati – volume: 13 start-page: 2264 year: 2017 ident: 10.1016/j.ab.2020.113636_bib20 article-title: Curcuminoid–BF2 complexes: synthesis, fluorescence and optimization of BF2 group cleavage publication-title: Beilstein J. Org. Chem. doi: 10.3762/bjoc.13.223 contributor: fullname: Weiss – volume: 7 start-page: 205 year: 2016 ident: 10.1016/j.ab.2020.113636_bib4 article-title: Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review publication-title: J. Tradit. Complement. Med. doi: 10.1016/j.jtcme.2016.05.005 contributor: fullname: Amalraj – volume: 21 start-page: 11 year: 2013 ident: 10.1016/j.ab.2020.113636_bib18 article-title: Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice publication-title: DARU J. Pharm. Sci. doi: 10.1186/2008-2231-21-11 contributor: fullname: Verma – volume: 102 start-page: 1095 year: 2019 ident: 10.1016/j.ab.2020.113636_bib12 article-title: Simultaneous determination of curcumin and resveratrol in lipidic nanoemulsion formulation and rat plasma using HPLC: optimization and application to real samples publication-title: J. AOAC Int. doi: 10.5740/jaoacint.18-0269 contributor: fullname: Nasr – volume: 129 start-page: 111 year: 1998 ident: 10.1016/j.ab.2020.113636_bib6 article-title: Inhibitory effect of curcuminoids on MCF-7 cell proliferation and structure–activity relationships publication-title: Canc. Lett. doi: 10.1016/S0304-3835(98)00092-5 contributor: fullname: Simon – volume: 41 start-page: 1640 year: 1993 ident: 10.1016/j.ab.2020.113636_bib10 article-title: Nematocidal activity of Turmeric : synergistic action of curcuminoids publication-title: Chem. Pharm. Bull. (Tokyo) doi: 10.1248/cpb.41.1640 contributor: fullname: Kiuchi – volume: 6 start-page: 257 year: 2014 ident: 10.1016/j.ab.2020.113636_bib17 article-title: Quantification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin in rodent brain by UHPLC/ESI-Q-TOF-MS/MS after intra-nasal administration of curcuminoids loaded PNIPAM nanoparticles publication-title: Drug Test. Anal. doi: 10.1002/dta.1472 contributor: fullname: Ahmad – volume: 25 start-page: 1144 year: 2011 ident: 10.1016/j.ab.2020.113636_bib14 article-title: A simple RP-HPLC method for the simultaneous determination of curcumin and its prodrug, curcumin didecanoate, in rat plasma and the application to pharmacokinetic study publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.1584 contributor: fullname: Han – volume: 51 start-page: 179 year: 1989 ident: 10.1016/j.ab.2020.113636_bib9 article-title: Studies on curcumin and curcuminoids. XV. Catalytic effect of demethoxy- and bisdemethoxycurcumin on the peroxidation of linoleic acid by 15-lipoxygenase publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(89)90253-6 contributor: fullname: Tønnesen – volume: 130 start-page: 765 year: 2007 ident: 10.1016/j.ab.2020.113636_bib1 article-title: From exotic spice to modern drug? publication-title: Cell doi: 10.1016/j.cell.2007.08.024 contributor: fullname: Singh – volume: 23 start-page: 1201 year: 2009 ident: 10.1016/j.ab.2020.113636_bib15 article-title: A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.1244 contributor: fullname: Li – volume: 1400 start-page: 1 year: 2011 ident: 10.1016/j.ab.2020.113636_bib7 article-title: A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease publication-title: Brain Res. doi: 10.1016/j.brainres.2011.05.022 contributor: fullname: Ahmed – volume: 28 start-page: 1765 year: 2007 ident: 10.1016/j.ab.2020.113636_bib8 article-title: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism publication-title: Carcinogenesis doi: 10.1093/carcin/bgm123 contributor: fullname: Sandur
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Snippet	A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated...
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SubjectTerms	Animals Boranes - chemistry Boron trifluoride (BF3) Chromatography, Liquid Curcumin Curcuminoids Diarylheptanoids - blood Diarylheptanoids - chemistry Diarylheptanoids - isolation & purification Healthy Volunteers Humans Liquid chromatography coupled mass spectrometry (LCMS) Mass Spectrometry Mice Molecular Structure Pharmacokinetics
Title	A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples
URI	https://dx.doi.org/10.1016/j.ab.2020.113636 https://www.ncbi.nlm.nih.gov/pubmed/32081619
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