Beyond kinetic traps in RNA folding

Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics. Several interdependent parameters that contribute to misfolding are now well understood and examples of large RNAs and ribonucleoproteins that avoid kinetic traps have been reported. Th...

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Bibliographic Details
Published in:	Current Opinion in Structural Biology Vol. 11; no. 3; pp. 309 - 314
Main Authors:	Treiber, Daniel K, Williamson, James R
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2001
Subjects:	b15 ribozyme divalent ions Exons folding kinetics kinetic trap Kinetics Nucleic Acid Conformation ribonucleoprotein Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism RNA - chemistry RNA - metabolism RNA folding Rnase P Tetrahymena ribozyme ribonucleoprotein Rnase P Tetrahymena ribozyme RNA folding folding kinetics b15 ribozyme Structural biology divalent ions kinetic trap
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Summary:	Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics. Several interdependent parameters that contribute to misfolding are now well understood and examples of large RNAs and ribonucleoproteins that avoid kinetic traps have been reported. These advances have facilitated the exploration of fundamental RNA folding processes that were previously inaccessible.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0959-440X 1879-033X
DOI:	10.1016/S0959-440X(00)00206-2