New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis

• Published in: Journal of natural medicines Vol. 67; no. 2; pp. 327 - 332
• Main Authors: Ghanadian, Syed Mustafa, Ayatollahi, Abdul Majid, Afsharypuor, Suleiman, Javanmard, Shaghayegh Haghjooy, Dana, Nasim
• Format: Journal Article
• Language: English
• Published: Japan Springer-Verlag 01-04-2013; Springer Japan
• Subjects: aerial parts; angiogenesis; Biomedical and Life Sciences; Biomedicine; Cells, Cultured; Complementary & Alternative Medicine; Diterpenes - chemistry; Diterpenes - pharmacology; diterpenoids; Endothelial Cells - cytology; Endothelial Cells - drug effects; endothelium; esters; Euphorbia; Euphorbia - chemistry; human umbilical vein endothelial cells; Humans; Magnetic Resonance Spectroscopy; Medicinal Chemistry; Original Paper; perennials; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Sciences; Umbilical Veins - cytology; Vascular Endothelial Growth Factor A - pharmacology; Anti-angiogenesis activity; Myrsinane diterpenoid
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-012-0686-3

Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2′-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on ¹³C- and ¹H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.