Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents

A series of combretastatin-amidobenzothiazole conjugates have been synthesized and evaluated for their anticancer activity. All these compounds exhibited significant anticancer activity and the most potent compound (11a) showed GI50 values ranging 0.019–11 μM. Biological studies such as cell cycle d...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 56; pp. 166 - 178
Main Authors:	Kamal, Ahmed, Mallareddy, Adla, Janaki Ramaiah, M., Pushpavalli, S.N.C.V.L., Suresh, Paidakula, Kishor, Chandan, Murty, J.N.S.R.C., Rao, N. Sankara, Ghosh, Sowjanya, Addlagatta, Anthony, Pal-Bhadra, Manika
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Masson SAS 01-10-2012 Elsevier
Subjects:	Anticancer activity Antimitotic Agents - chemical synthesis Antimitotic Agents - chemistry Antimitotic Agents - pharmacology Benzothiazoles - chemistry Benzothiazoles - pharmacology Bibenzyls - chemistry Bibenzyls - pharmacology Biological and medical sciences CA-4 Cell cycle Cell Cycle - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor ERK Humans MCF-7 Cells Medical sciences Miscellaneous Models, Molecular Molecular Dynamics Simulation Molecular modeling Molecular Structure Pharmacology. Drug treatments Polymerization Structure-Activity Relationship Tubulin Tubulin - metabolism Tumor Cells, Cultured CA-4 Tubulin Molecular modeling Cell cycle Anticancer activity ERK
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