Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation

OBJECTIVE:Epinephrine given during closed-chest resuscitation increases blood flow across the coronary and cerebral circuits. However, epinephrine worsens reperfusion arrhythmias and intensifies postresuscitation myocardial dysfunction. We investigated whether cariporide—a selective sodium-hydrogen...

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Bibliographic Details
Published in:	Critical care medicine Vol. 33; no. 11; pp. 2599 - 2605
Main Authors:	Ayoub, Iyad M, Kolarova, Julieta, Kantola, Ronald L, Sanders, Robert, Gazmuri, Raúl J
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD by the Society of Critical Care Medicine and Lippincott Williams & Wilkins 01-11-2005 Lippincott
Subjects:	Adrenergic beta-Agonists - adverse effects Adrenergic beta-Agonists - therapeutic use Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Anti-Arrhythmia Agents - pharmacology Biological and medical sciences Cardiology. Vascular system Coronary heart disease Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Epinephrine - adverse effects Epinephrine - antagonists & inhibitors Epinephrine - therapeutic use Guanidines - pharmacology Heart Intensive care medicine Male Medical sciences Myocardial Ischemia - chemically induced Myocardial Ischemia - prevention & control Resuscitation - methods Sulfones - pharmacology Swine Ventricular Fibrillation - drug therapy Epinephrine Intensive care Arrhythmia Hydrogen Cardioprotective agent Cariporide Cardiovascular disease Myocardial ischemia Catecholamine sodium-hydrogen antiporter Coronary heart disease Myocardial disease Excitability disorder Ventricular fibrillation Vascular disease cardiopulmonary resuscitation Sodium Resuscitation
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