Flt3 ligand promotes myeloid dendritic cell differentiation of human hematopoietic progenitor cells: Possible application for cancer immunotherapy

Current in vitro culture systems allow the generation of human dendritic progenitor cells (CFU-DCs). The aim of this study was to assess the effect of Flt3 ligand (FL) on the proliferation of human peripheral blood-derived myeloid CFU-DCs and their differentiation into more committed precursor cells...

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Bibliographic Details
Published in:	International journal of oncology Vol. 30; no. 6; pp. 1461 - 1468
Main Authors:	HARADA, Sachio, KIMURA, Takafumi, FUJIKI, Hiroshi, NAKAGAWA, Hitoshi, UEDA, Yuji, ITOH, Tsuyoshi, YAMAGISHI, Hisakazu, SONODA, Yoshiaki
Format:	Journal Article
Language:	English
Published:	Athens Editorial Academy of the International Journal of Oncology 01-06-2007
Subjects:	Antigens, CD34 - metabolism Biological and medical sciences Cell Differentiation - immunology Cell Proliferation Cells, Cultured Dendritic Cells - cytology Dendritic Cells - metabolism Flow Cytometry Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans Immunotherapy - methods Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Medical sciences Membrane Proteins - immunology Membrane Proteins - metabolism Myeloid Progenitor Cells - cytology Myeloid Progenitor Cells - metabolism Neoplasms - therapy T-Lymphocytes - immunology T-Lymphocytes - metabolism Thrombopoietin - immunology Thrombopoietin - metabolism Tumors Human Dendritic cell Flt3 ligand Stem cell Hematopoietic cell hematopoietic progenitor cell Malignant tumor Cell differentiation Cell subpopulation CD34+ cell Cell immunotherapy Cancerology Treatment Antigen presenting cell cancer immunotherapy Myeloid dendritic cell Tumor cell Cancer
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