Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis

• Published in: Journal of diabetes and its complications Vol. 38; no. 2; p. 108690
• Main Authors: Ruiz-Muñoz, Maria, Martinez-Barrios, Francisco-Javier, Fernandez-Torres, Raul, Lopezosa-Reca, Eva, Marchena-Rodriguez, Ana
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2024; Elsevier Limited
• Subjects: Amputation; Autologous growth factors; Bias; Content analysis; Diabetes; Diabetic foot disease; Epidermal growth factor; Foot diseases; Kappa coefficient; Meta-analysis; Platelet-rich plasma; Randomised controlled trials; Software; Statistical analysis; Systematic review; Ulcer treatment; Ulcers; Vascular endothelial growth factor; Autologous growth factors; Randomised controlled trials; Ulcer treatment; Platelet-rich plasma; Diabetic foot disease; Meta-analysis
• DOI: 10.1016/j.jdiacomp.2024.108690
• EISSN: 1873-460X
• ISSN: 1056-8727

This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.
The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0.
Eleven RCTs with 828 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I2 = 0 %) in growth factors based in autologous platelech-rich plasma (aPRP) group compared with control. Mixed evidence was seen for publication bias, but analyses by using the trim-and-fill method did not appreciably alter results.
Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.
•Foot complications in diabetic patients are a major cause of extended hospital stays.•15% of diabetics will develop foot disease, with 25% of cases resulting in lower limb amputation.•The current standard hospital treatments for patients with diabetic foot disease, do not guarantee success in their closure.•Using aPRP is a cost-effective and highly efficient treatment that effectively stimulates cell proliferation and differentiation.