Cadmium-113 Nuclear Magnetic Resonance Studies of Bovine Insulin: Two-Zinc Insulin Hexamer Specifically Binds Calcium

By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion bin...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 212; no. 4494; pp. 560 - 562
Main Authors:	Sudmeier, J. L., Bell, S. J., Storm, M. C., Dunn, M. F.
Format:	Journal Article
Language:	English
Published:	United States The American Association for the Advancement of Science 01-05-1981 American Association for the Advancement of Science
Subjects:	Animals Binding Sites Cadmium Calcium (Nutrient) Calcium - metabolism Calcium in the body Carboxylates Cattle Chemical equilibrium Grants Insulin Insulin - metabolism Isotopes Ligands Macromolecular Substances Magnetic Resonance Spectroscopy Metal ions Nuclear magnetic resonance Protein Conformation Ungulates Zinc Zinc - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion binding sites.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7010607