Influence of the drying technique on theophylline pellets prepared by extrusion–spheronization

• Published in: International journal of pharmaceutics Vol. 242; no. 1; pp. 349 - 351
• Main Authors: PEREZ, J. P, RABISKOVA, M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 21-08-2002; Elsevier
• Subjects: Avicel® CL-611; Biological and medical sciences; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - chemistry; Cellulose; Desiccation - methods; Drug Compounding - methods; Drying; Excipients; Extrusion; General pharmacology; Hardness; Medical sciences; Particle Size; Pellet; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Spheronization; Theophylline; Theophylline - administration & dosage; Theophylline - chemistry; Spheronization; Pellet; Extrusion; Avicel® CL-611; Theophylline; Drying; Temperature; Pharmaceutical technology; Drug adjuvant; Fabrication property relation; Microwave oven; Drying oven; Dosage form; Xanthine derivatives; Pellet(dosage form); Physicochemical properties; Fluidized bed
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/S0378-5173(02)00214-4

Extrusion–spheronization is frequent method for pellet production and especially extrusion stage has been studied for its influence on pellet properties. However, the formation of pellet structure is not finished before drying stage. The possible influence of different drying methods and used temperatures on some properties of pellets, containing theophylline as active ingredient and Avicel® CL-611 as spheronizing agent, is the object of this paper.