Measurement and metabolism of isoflavonoids and lignans in the human male

• Published in: Cancer letters Vol. 114; no. 1; pp. 145 - 151
• Main Authors: Morton, M.S., Matos-Ferreira, A., Abranches-Monteiro, L., Correia, R., Blacklock, N., Chan, P.S.F., Cheng, C., Lloyd, S., Chieh-ping, Wu, Griffiths, K.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Shannon Elsevier Ireland Ltd 19-03-1997; Elsevier
• Subjects: Adult; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Foods and miscellaneous; Gas Chromatography-Mass Spectrometry; Glycine max - metabolism; Humans; Isoflavones; Isoflavones - analysis; Isoflavones - metabolism; Lignans; Lignans - analysis; Lignans - metabolism; Linseed Oil - metabolism; Male; Mass spectrometer; Medical sciences; Middle Aged; Prostate - metabolism; Prostate cancer; Soya; Time Factors; Tumors; Asia; Europe; Soya; Mass spectrometer; Prostate cancer; Lignans; Isoflavones; Human; Urinary system disease; Prostate disease; Estrogen; Supplemented diet; Soybean; Malignant tumor; Anticarcinogen; Metabolism; Normal; Isoflavone derivatives; Prevention; Plant origin; Lignan; Male genital diseases; Prostatic fluid; Prostate; Comparative study
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(97)04646-6

Asian men, who consume a low fat/high fibre soya-based diet, have very much lower incidence of prostate cancer than men from North America and Europe. The soya bean is a rich source of the isoflavonic phyto-oestrogens, daidzein, genistein and equol, compounds which may be cancer-protective in Asian populations. The lignans, enterolactone and enterodiol, plant oestrogens derived from cereals and vegetables, may act in a similar manner in vegetarian men. We report here on the measurement of isoflavonoids and lignans, by gas chromatography-mass spectrometry, in prostatic fluid of men from Asia and Europe and also on the metabolism of these compounds in Western men following dietary supplementation.