Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii
Erycristagallin, a pterocarpene isolated from Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) free radical and on the arachidonic acid metabolism. In addition, erycristagallin was tested on different experimental models of...
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| Published in: | European journal of pharmacology Vol. 468; no. 1; pp. 67 - 74 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
02-05-2003
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| Abstract | Erycristagallin, a pterocarpene isolated from
Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) free radical and on the arachidonic acid metabolism. In addition, erycristagallin was tested on different experimental models of inflammation, such as the acute and chronic inflammation induced by the application of 12-
O-tetradecanoylphorbol 13-acetate (TPA) on mice and the phospholipase A
2-induced mouse paw oedema test. In the carrageenan-induced mouse paw oedema test, the ethyl acetate extract obtained from
E. mildbraedii showed anti-inflammatory activity, and erycristagallin was isolated as the active principle. In vivo, erycristagallin significantly inhibited the phospholipase A
2-induced mouse paw oedema as well as the mouse ear oedema induced by TPA (ID
50<10 μg/ear). Moreover, it significantly reduced the chronic inflammation and leukocyte infiltration induced by repeated application of TPA. In vitro, erycristagallin inhibited the arachidonic acid metabolism via the 5-lipoxygenase pathway in rat polymorphonuclear leukocytes (IC
50=23.4 μM), but had no effect on cyclooxygenase-1 metabolism in human platelets, while showing antioxidant activity in the DPPH test. As with other phenolics, the anti-inflammatory activity of erycristagallin may be based on its capacity to inhibit the arachidonic acid metabolism via the 5-lipoxygenase pathway. |
|---|---|
| AbstractList | Erycristagallin, a pterocarpene isolated from Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) free radical and on the arachidonic acid metabolism. In addition, erycristagallin was tested on different experimental models of inflammation, such as the acute and chronic inflammation induced by the application of 12-O-tetradecanoylphorbol 13-acetate (TPA) on mice and the phospholipase A(2)-induced mouse paw oedema test. In the carrageenan-induced mouse paw oedema test, the ethyl acetate extract obtained from E. mildbraedii showed anti-inflammatory activity, and erycristagallin was isolated as the active principle. In vivo, erycristagallin significantly inhibited the phospholipase A(2)-induced mouse paw oedema as well as the mouse ear oedema induced by TPA (ID(50)<10 microg/ear). Moreover, it significantly reduced the chronic inflammation and leukocyte infiltration induced by repeated application of TPA. In vitro, erycristagallin inhibited the arachidonic acid metabolism via the 5-lipoxygenase pathway in rat polymorphonuclear leukocytes (IC(50)=23.4 microM), but had no effect on cyclooxygenase-1 metabolism in human platelets, while showing antioxidant activity in the DPPH test. As with other phenolics, the anti-inflammatory activity of erycristagallin may be based on its capacity to inhibit the arachidonic acid metabolism via the 5-lipoxygenase pathway. Erycristagallin, a pterocarpene isolated from Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) free radical and on the arachidonic acid metabolism. In addition, erycristagallin was tested on different experimental models of inflammation, such as the acute and chronic inflammation induced by the application of 12- O-tetradecanoylphorbol 13-acetate (TPA) on mice and the phospholipase A 2-induced mouse paw oedema test. In the carrageenan-induced mouse paw oedema test, the ethyl acetate extract obtained from E. mildbraedii showed anti-inflammatory activity, and erycristagallin was isolated as the active principle. In vivo, erycristagallin significantly inhibited the phospholipase A 2-induced mouse paw oedema as well as the mouse ear oedema induced by TPA (ID 50<10 μg/ear). Moreover, it significantly reduced the chronic inflammation and leukocyte infiltration induced by repeated application of TPA. In vitro, erycristagallin inhibited the arachidonic acid metabolism via the 5-lipoxygenase pathway in rat polymorphonuclear leukocytes (IC 50=23.4 μM), but had no effect on cyclooxygenase-1 metabolism in human platelets, while showing antioxidant activity in the DPPH test. As with other phenolics, the anti-inflammatory activity of erycristagallin may be based on its capacity to inhibit the arachidonic acid metabolism via the 5-lipoxygenase pathway. Erycristagallin, a pterocarpene isolated from Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable 2,2-diphenyl-1-pycryl-hydrazyl (DPPH) free radical and on the arachidonic acid metabolism. In addition, erycristagallin was tested on different experimental models of inflammation, such as the acute and chronic inflammation induced by the application of 12-O-tetradecanoylphorbol 13-acetate (TPA) on mice and the phospholipase A(2)-induced mouse paw oedema test. In the carrageenan-induced mouse paw oedema test, the ethyl acetate extract obtained from E. mildbraedii showed anti-inflammatory activity, and erycristagallin was isolated as the active principle. In vivo, erycristagallin significantly inhibited the phospholipase A(2)-induced mouse paw oedema as well as the mouse ear oedema induced by TPA (ID(50)<10 microg/ear). Moreover, it significantly reduced the chronic inflammation and leukocyte infiltration induced by repeated application of TPA. In vitro, erycristagallin inhibited the arachidonic acid metabolism via the 5-lipoxygenase pathway in rat polymorphonuclear leukocytes (IC(50)=23.4 microM), but had no effect on cyclooxygenase-1 metabolism in human platelets, while showing antioxidant activity in the DPPH test. As with other phenolics, the anti-inflammatory activity of erycristagallin may be based on its capacity to inhibit the arachidonic acid metabolism via the 5-lipoxygenase pathway. |
| Author | Fomum, Zacharias Tanee Njamen, Dieudonné Mbafor, Joseph Tanyi Kamanyi, Albert Rı́os, José Luis Mbanya, Jean-Claude Talla, Emmanuel Cerdá-Nicolás, Miguel Recio, M.Carmen Giner, Rosa M. |
| Author_xml | – sequence: 1 givenname: Dieudonné surname: Njamen fullname: Njamen, Dieudonné organization: Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon – sequence: 2 givenname: Emmanuel surname: Talla fullname: Talla, Emmanuel organization: Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon – sequence: 3 givenname: Joseph Tanyi surname: Mbafor fullname: Mbafor, Joseph Tanyi organization: Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon – sequence: 4 givenname: Zacharias Tanee surname: Fomum fullname: Fomum, Zacharias Tanee organization: Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon – sequence: 5 givenname: Albert surname: Kamanyi fullname: Kamanyi, Albert organization: Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon – sequence: 6 givenname: Jean-Claude surname: Mbanya fullname: Mbanya, Jean-Claude organization: Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon – sequence: 7 givenname: Miguel surname: Cerdá-Nicolás fullname: Cerdá-Nicolás, Miguel organization: Departament de Patologia, Facultat de Medicina, Universitat de València, Valencia, Spain – sequence: 8 givenname: Rosa M. surname: Giner fullname: Giner, Rosa M. organization: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Vicent Andrés Estellés s/n, Burjassot, Valencia 46100, Spain – sequence: 9 givenname: M.Carmen surname: Recio fullname: Recio, M.Carmen organization: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Vicent Andrés Estellés s/n, Burjassot, Valencia 46100, Spain – sequence: 10 givenname: José Luis surname: Rı́os fullname: Rı́os, José Luis email: riosjl@uv.es organization: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Vicent Andrés Estellés s/n, Burjassot, Valencia 46100, Spain |
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| Keywords | 5-Lipoxygenase inhibition Erythrina mildbraedii Arachidonic acid metabolism Anti-inflammatory activity Erycristagallin |
| Language | English |
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Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable... Erycristagallin, a pterocarpene isolated from Erythrina mildbraedii, was tested in vitro for its antioxidant properties on the stable... |
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| SubjectTerms | 5-Lipoxygenase inhibition Animals Anti-inflammatory activity Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Arachidonic Acid - metabolism Biological and medical sciences Biphenyl Compounds Carrageenan Ear - pathology Edema - chemically induced Edema - drug therapy Erycristagallin Erythrina - chemistry Erythrina mildbraedii Female Free Radical Scavengers - pharmacology Heterocyclic Compounds, 4 or More Rings Hindlimb - pathology Isoflavones - isolation & purification Isoflavones - pharmacology Leukotriene B4 - metabolism Medical sciences Mice Phospholipases A Picrates - metabolism Plant Extracts - pharmacology Rats Rats, Wistar |
| Title | Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii |
| URI | https://dx.doi.org/10.1016/S0014-2999(03)01664-9 https://www.ncbi.nlm.nih.gov/pubmed/12729844 https://search.proquest.com/docview/73240425 |
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