The voltage- and time-dependent blocking effect of trifluoperazine on T lymphocyte Kv1.3 channels

Phenothiazines are well-known calmodulin inhibitors that interact with many receptors and channels including a variety of potassium channels. In this study, we report a blocking effect of trifluoperazine (TFP) on voltage-gated Kv1.3 channels expressed in human T lymphocytes. Application of TFP in th...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 65; no. 4; pp. 551 - 561
Main Authors:	Teisseyre, Andrzej, Michalak, Krystyna
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15-02-2003 Elsevier Science
Subjects:	Biological and medical sciences Electrophysiology Humans In Vitro Techniques Kv1.3 Potassium Channel Medical sciences Membrane Potentials - drug effects Neuropharmacology Patch-clamp Pharmacology. Drug treatments Phenothiazines Potassium channel Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Potassium Channels - physiology Potassium Channels, Voltage-Gated Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology T lymphocyte T-Lymphocytes - drug effects T-Lymphocytes - metabolism T-Lymphocytes - physiology Time Factors Trifluoperazine Trifluoperazine - pharmacology TL, human T lymphocyte V i, inactivation midpoint Trifluoperazine Phenothiazines τ i, inactivation time constant V rev, reversal potential of the current I rel, relative peak current I contr60, current amplitude recorded on the same cell under control conditions at +60 mV g K −120, chord conductance recorded on the same cell from the holding potential of −120 mV Patch-clamp g K, chord conductance TMX, tamoxifen τ n, activation time constant TFP, trifluoperazine g K norm, normalised relative chord conductance V n, activation midoint I, current amplitude 4-AP, 4-aminopyridine k i, steepness of the voltage dependence (inactivation) T lymphocyte g K 60, chord conductance recorded on the same cell at +60 mV V, membrane potential k n, steepness of the voltage dependence (activation) Potassium channel Potassium Cations Neuroleptic Psychotropic Electrophysiology Patch clamp method Activation Ionic channel Phenothiazine derivatives Ionic current Inactivation Concentration effect T-Lymphocyte Membrane potential
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