Expression and characterization of the chemokine receptor CCR2B from rhesus monkey

Species selectivity of chemokine receptor antagonists is a potential deterrent to making preclinical assessments in vivo. To determine if rhesus monkey disease models could support these assessments, we pharmacologically and functionally characterized recombinant rhesus CCR2B receptor. For these stu...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 66; no. 2; pp. 321 - 330
Main Authors:	Jin, Hong, Vicario, Pasquale P., Zweerink, Hans, Goyal, Shefali, Hanlon, William A., Dorn, Conrad P., Mills, Sander G., DeMartino, Julie A., Cascieri, Margaret A., Struthers, Mary
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15-07-2003 Elsevier Science
Subjects:	Amino Acid Sequence Animals Antagonist Biological and medical sciences Calcium - metabolism CCR2B Chemokine Chemokine CCL2 - metabolism CHO Cells Cloning, Molecular Cricetinae Female Flow Cytometry Humans Macaca mulatta MCP-1 Medical sciences Molecular Sequence Data Radioligand Assay Receptor Receptors, CCR2 Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Rhesus monkey Sequence Homology, Amino Acid Transfection MCP-1 RANTES EAE MIG MDC CCR2B Chemokine Rhesus monkey GF/B HIV MIP Receptor FBS TARC Antagonist COPD Rhesus monkeys
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