Enhancement of vascular targeting by inhibitors of nitric oxide synthase

This study investigates the enhancement of the vascular targeting activity of the tubulin-binding agent combretastatin A4 phosphate (CA4P) by various inhibitors of nitric oxide synthases. The syngeneic tumors CaNT and SaS growing in CBA mice were used for this study. Reduction in perfused vascular v...

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Bibliographic Details
Published in:	International journal of radiation oncology, biology, physics Vol. 54; no. 5; p. 1532
Main Authors:	Davis, Peter D, Tozer, Gillian M, Naylor, Matthew A, Thomson, Peter, Lewis, Gemma, Hill, Sally A
Format:	Journal Article
Language:	English
Published:	United States 01-12-2002
Subjects:	Angiogenesis Inhibitors - therapeutic use Animals Antineoplastic Agents, Phytogenic - therapeutic use Benzimidazoles - pharmacology Enzyme Inhibitors - pharmacology Fluorescent Dyes - pharmacology Mice Mice, Inbred CBA Models, Chemical Necrosis Neovascularization, Pathologic Nitric Oxide Synthase - antagonists & inhibitors Stilbenes - therapeutic use Time Factors Tubulin - metabolism Tumor Cells, Cultured
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